Science
Mechanism of Action
Rhodomyrtus Tomentosa Fruit Extract exerts robust antimicrobial activity against specific Cutibacterium acnes phylotypes, thereby modulating the dermal microbiota and inhibiting C. acnes proliferation to alleviate acne. It also regulates sebum production by inhibiting 5-alpha reductase and reducing lipid peroxidation, which contributes to diminished pore size, decreased shine, and balanced oil levels. Additionally, this extract possesses antioxidant properties, effectively scavenging free radicals, and demonstrates anti-inflammatory traits by suppressing cytokines, soothing erythema, and enhancing barrier function. It further offers photoprotective benefits, aiding in DNA repair and reducing UVB-induced inflammatory mediators.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 A 28-day clinical study utilizing a 2% concentration demonstrated a significant 41% reduction in skin sebum and a 21% reduction in redness among acne subjects. This application also favorably modified Cutibacterium acnes phylotype repartition, leading to a decrease in both retentional and inflammatory lesions.
- 02 Formulations containing rhodomyrtone, a key compound within the extract, effectively reduced acne lesions and inflammation, showing comparable efficacy to clindamycin without inducing skin irritation or microbial resistance.
- 03 A cream incorporating 5 wt% of a combination extract, including Rhodomyrtus Tomentosa, significantly improved facial acne and redness over a 28-day period in 30 subjects with sensitive and acne-prone skin.
Transparency
Dusting Analysis
Clinical studies confirm significant efficacy at concentrations as low as 2%, with effective application up to 5%. This data suggests that using sub-efficacious concentrations below this range would not yield the observed benefits.
The Formula
Formulation
Stability
Extraction is typically performed using hydroalcoholic solutions (e.g., ethanol/water 50/50). The concentrated extract can be formulated into a water/propane 1,3-diol (50/50) matrix for stability.
Safety
Safety Profile
Rhodomyrtus Tomentosa Fruit Extract exhibits a low hazard profile across various toxicological categories, including cancer, allergies, immunotoxicity, and reproductive toxicity, supported by limited but consistent data. Clinical evaluations confirm its non-irritating and non-sensitizing properties in topical applications, even at a 5% concentration, showing excellent skin compatibility, no eye irritation at 2%, and no phototoxic or mutagenic effects. The active ingredient Acnilys, which contains this extract, is FDA Compliant.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A multi-functional powerhouse, Rhodomyrtus Tomentosa Fruit Extract is valuable for its precise microbiome balancing, significant sebum reduction, and soothing anti-inflammatory actions, particularly for acne-prone, oily, and sensitive skin types.
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References
Sources