Science
Mechanism of Action
Rhodomyrtus tomentosa Flower/Leaf/Stem Extract exerts its antioxidant effects through a high concentration of polyphenols, effectively neutralizing free radicals and protecting against environmental stressors. Its anti-inflammatory capabilities are attributed to flavonoids, which suppress TNF-α expression, down-regulate key inflammatory genes (IL-1β, IL-8, iNOS, SAA, Hepcidin), and reduce reactive oxygen species (ROS) and prostaglandin E2 levels. Tannins and essential oils contribute to its antimicrobial and antibacterial efficacy, particularly against Cutibacterium acnes, thereby assisting in the modulation of the skin's microbiota. The extract offers skin conditioning benefits, enhancing texture and appearance, while its astringent properties derived from tannins contribute to skin tightening and pore refinement. Notably, key active compounds like rhodomyrtone have demonstrated anti-psoriasis potential by inhibiting keratinocyte hyperproliferation.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 In a 28-day clinical trial, a 2% Rhodomyrtus tomentosa fruit extract gel significantly modified skin microbiota in acne subjects, reducing Cutibacterium acnes phylotype IA1 while increasing phylotypes II and III. This application led to a reduction in both retentional and inflammatory lesions.
- 02 When combined at 5 wt% with Guaiacum officinale extract, Rhodomyrtus tomentosa extract significantly improved facial acne and redness over a 28-day clinical trial, achieving a 50.00% reduction in comedones and a 30.65% reduction in papules, with no observed adverse events.
- 03 Rhodomyrtone, a key compound, suppressed HaCaT keratinocyte cell viability in vitro at concentrations of 2-32 μg/mL, suggesting its potential as a natural anti-psoriasis agent. In vivo studies confirmed no skin irritation.
- 04 An 80% ethanol extract derived from the fruit exhibited protective effects against UVB-induced cytotoxicity in normal human epidermal keratinocytes (NHEK), reduced UVB-induced cyclobutane pyrimidine dimers, and decreased prostaglandin E2 secretion, indicating photoprotective properties.
- 05 Rhodomyrtone demonstrated extremely potent and broad Gram-positive antibacterial activity with a Minimum Inhibitory Concentration (MIC) ranging from 0.39-0.78 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Formulations such as lip gloss containing this extract demonstrated stability at room temperature for 30 days within a pH range of 6.2-6.4. Gel formulations also exhibited stability through freeze-thaw cycles without significant changes in pH or sedimentation.
Synergies
- Guaiacum officinale extract (for enhanced acne and redness improvement)
Safety
Safety Profile
Generally regarded as safe for use in cosmetic and personal care formulations. In vivo studies involving rhodomyrtone consistently reported no skin irritation. Clinical trials, including those using a 5 wt% combined extract and lip gloss formulations up to 14% extract, have shown no adverse events or irritation. A patch test yielded a rating score of 0.0, indicating a 'safe product' classification. Adherence to legally mandated rigorous safety assessments for cosmetic ingredients is presumed.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rhodomyrtus tomentosa Flower/Leaf/Stem Extract is a highly valuable botanical ingredient, offering a broad spectrum of scientifically supported benefits for skin health, including managing acne, inflammation, and oxidative stress, with a favorable safety profile for diverse skin types.
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References
Sources