RHODODENDRON YEDOENSE FLOWER EXTRACT.

The primary mechanism of Rhododendron yedoense flower extract is attributed to its high concentration of flavonoids, including quercetin, quercitrin, and myricitrin-5-methyl ether. These molecules act as potent antioxidants, effectively scavenging oxygen radicals like DPPH, TBARS, and superoxide anion radicals, thereby reducing oxidative stress. Beyond direct antioxidant activity, studies on other Rhododendron species indicate anti-inflammatory properties achieved by reducing intracellular reactive oxygen species (ROS) and inhibiting nuclear factor-κB (NF-κB) nuclear transcription, specifically through the phosphorylation inhibition of NF-κB, IkBα, and IKKα/β. Additionally, some Rhododendron flower extracts have demonstrated the ability to inhibit melanin formation, suggesting potential for evening skin tone.