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RHODODENDRON FERRUGINEUM EXTRACT.

Valuable CAS 90106-21-1 / FRAGRANCE, SKIN PROTECTING

Sourced from the Alpine Rose, Rhododendron Ferrugineum Extract is a sophisticated botanical ingredient engineered to address key markers of skin aging. It precisely targets and eliminates senescent cells, thereby mitigating inflammatory responses and enhancing overall skin vitality. This extract effectively improves skin elasticity and visibly diminishes redness for a more resilient and youthful complexion.

Summary

Antioxidant Skin protecting Masking Senolytic Anti-inflammatory Barrier-enhancing Collagen synthesis booster Skin regeneration Elasticity improver Redness reduction

Science

Mechanism of Action

This extract operates through a multi-modal mechanism, primarily exhibiting senolytic activity by selectively eliminating senescent ('aged') cells that drive chronic inflammation and accelerate skin aging. This targeted action is attributed to specific flavonoids, including hyperoside and taxifolin, which induce apoptosis through the inhibition or downregulation of Bcl-2. Furthermore, its rich composition of flavonoids and phenolic acids confers potent antioxidant protection, shielding the skin from oxidative stress and environmental damage. The extract also actively supports skin regeneration, promotes collagen synthesis to enhance structural integrity, strengthens the skin barrier function, and provides anti-inflammatory benefits via its phenolic acids and triterpene compounds, collectively boosting skin resilience.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

2%

Key findings

  1. 01 Significantly decreased skin redness and increased skin elasticity
  2. 02 Increased vitality and proliferation rates of epithelial HaCaT keratinocytes

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract exhibits heat stability below 60°C. It should be seamlessly integrated into the aqueous phase of a formulation or added pre-dissolved during the cooling phase once temperatures have dropped below 60°C.

Conflicts

  • Water-free formulations

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Rhododendron Ferrugineum Extract is certified by COSMOS and NATRUE, aligning with stringent natural and organic cosmetic standards. SkinSAFE identifies this ingredient as 'Irritant Free', and in vitro studies confirm no toxic effects on epithelial HaCaT keratinocytes at concentrations up to 100 µg/mL. While some non-specific Rhododendron extracts have shown cytotoxic effects at significantly higher concentrations (500 µg/mL) in general cytotoxicity assessments, this specific extract demonstrates a favorable safety profile at typical cosmetic usage levels.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rhododendron Ferrugineum Extract is a valuable senolytic and antioxidant ingredient, clinically demonstrated to reduce skin redness and enhance elasticity, making it highly effective for combating multiple signs of aging across all skin types.

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