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Moumoujus

RHODIOLA SACRA CALLUS.

Valuable / HUMECTANT, SKIN CONDITIONING - EMOLLIENT

Rhodiola Sacra Callus is an adaptogenic plant extract, harnessing the inherent resilience of the Rhodiola Sacra plant's cellular defenses. It provides a spectrum of benefits, acting as a potent antioxidant and anti-inflammatory agent, while actively supporting skin barrier integrity and vital collagen production. This multi-functional ingredient is engineered to fortify the skin against environmental aggressors and mitigate visible signs of aging.

Summary

Antioxidant Anti-inflammatory Skin Barrier Support Anti-aging Collagen Synthesis Booster Photoaging Protection Skin Conditioning Melanogenesis Modulation Wound Healing Support

Science

Mechanism of Action

Rhodiola Sacra Callus functions as an adaptogen, enhancing the skin's intrinsic capacity to adapt and resist environmental stressors. It exhibits significant antioxidant activity by neutralizing free radicals, thereby protecting cellular components from oxidative damage induced by UV radiation and pollutants. The ingredient also demonstrates robust anti-inflammatory properties, specifically inhibiting pro-inflammatory cytokines such as IL-6, enzymes like cyclooxygenase-1 (COX-1), COX-2, and phospholipase A2 (PLA2), and down-regulating neurogenic inflammation via neuropeptides (calcitonin-gene-related peptide, substance P). Furthermore, it supports skin regeneration by aiding barrier repair, reducing transepidermal water loss, and alleviating erythema. Its anti-aging efficacy is attributed to stimulating fibroblast activity, increasing the production of Type I and Type III collagen, and inhibiting metalloproteinase enzymes (MMP-1, MMP-9) responsible for collagen degradation. Emerging data also suggests a potential role in modulating melanogenesis for improved skin tone uniformity and promoting wound healing through enhanced cellular proliferation and collagen synthesis.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies at this concentration demonstrated inhibition of the pro-inflammatory cytokine IL-6 in human skin keratinocytes, alongside significant antioxidant activity.
  2. 02 A fermented Rhodiola rosea extract at this IC50 concentration significantly improved free radical scavenging, increased Type I and Type III collagen levels, and inhibited collagen-deading metalloproteinases (MMP-1 and MMP-9) in UVA-damaged fibroblasts, indicative of anti-photoaging effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for Rhodiola Sacra Callus stability is not documented. However, general Rhodiola extracts are versatile, existing in both water-soluble and oil-soluble forms depending on processing. Stability in nanoemulsions of Rhodiola rosea has been observed to be influenced by surfactant selection.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific CIR, SCCS, or FDA safety review for RHODIOLA SACRA CALLUS has been published. The related ingredient 'Rhodiola Rosea Callus Extract' is listed in CosIng for 'SKIN PROTECTING' benefits, without specific SCCS restrictions. Topically, Rhodiola rosea is generally well-tolerated with few reported side effects.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rhodiola Sacra Callus is a valuable adaptogenic ingredient offering robust antioxidant, anti-inflammatory, and anti-aging benefits, making it an excellent choice for enhancing skin resilience and overall health.

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