Science
Mechanism of Action
Rhizophora Mangle Extract operates through multifaceted mechanisms to benefit the skin. Its potent antioxidant action involves scavenging free radicals, inhibiting lipid peroxidation, and elevating the activity of vital antioxidant enzymes such as glutathione peroxidase and superoxide dismutase. It demonstrates anti-inflammatory efficacy by diminishing inflammatory cell presence and aiding the restoration of prostaglandin E2 (PGE(2)) levels. Furthermore, it exhibits antibacterial properties. For tissue repair, it promotes wound healing via enhanced wound contraction, stimulated angiogenesis, fibroblast proliferation, increased collagen fiber density, and elevated hydroxyproline content. Mechanistically, it may also contribute to anti-aging by inhibiting elastase activity and fostering collagen synthesis. Additional findings suggest antimutagenic properties through interaction with metallic ions and facilitation of DNA repair processes.
Research
Clinical Evidence
High confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Tinctures exhibited good stability across pH 3-7, with leaf tinctures showing particular stability at pH 5. The extract's soluble components are generally noted for high polarity.
Safety
Safety Profile
Animal studies revealed no toxicological signs. Human clinical trials reported no adverse effects following topical application for wound healing and oral aphthous ulcers. No cytotoxicity was observed in RAW 264.7 cells at tested concentrations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rhizophora Mangle Extract is a valuable botanical ingredient, clinically demonstrated for its significant wound healing, anti-inflammatory, and antioxidant properties, showing promising potential for overall skin health and regeneration.
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References
Sources