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Moumoujus

RHINACANTHUS NASUTUS LEAF EXTRACT.

Valuable / SKIN CONDITIONING

Rhinacanthus nasutus Leaf Extract is a botanical ingredient recognized for its calming, antioxidant, and clarifying properties. Rich in polyphenols and naphthoquinones, it helps soothe irritation and protect the skin from environmental stressors. It also exhibits antimicrobial activity, supporting a clearer complexion.

Summary

antioxidant soothing antimicrobial anti-inflammatory anti-allergic antifungal antiviral

Science

Mechanism of Action

This extract works by reducing skin redness and discomfort post-cleansing, providing a calming effect. Its antioxidant defense stems from polyphenols and naphthoquinones (rhinacanthins), which combat environmental free radical damage, including from UV exposure and pollution. Furthermore, its antimicrobial action helps clarify the skin by targeting common bacteria associated with congestion, such as *Staphylococcus epidermidis* and *Propionibacterium acnes*. It also demonstrates anti-inflammatory, anti-allergic, antifungal, and antiviral capabilities, with fungicidal action specifically linked to disrupting fungal cell walls.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–1%
Optimal

N/A

Key findings

  1. 01 A formulated toner containing Rhinacanthus nasutus Leaf Extract, tested at concentrations from 0.001 to 1.0 mg/mL, demonstrated safety in HDFa cytotoxicity tests with cell survival rates between 78.37% and 94.00%. Human volunteer trials confirmed its safety and physical stability, yielding a Mean Irritation Index (MII) of 0.00, indicating no irritation. However, this specific formulation did not show effectiveness in sebum control when compared to a placebo.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Formulations containing Rhinacanthus nasutus extract have shown good physical stability. It exhibits good solubility in water, alcohol, acetone, and DMSO, but is insoluble in ethyl acetate, chloroform, and hexane.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The extract, at concentrations up to 1.0 mg/mL, demonstrated high cell survival rates (78.37 – 94.00%) in HDFa cytotoxicity tests. A formulated toner showed good physical stability and was safe in human volunteers with an MII score of 0.00, indicating no irritation. Additionally, a root extract gel (containing 0.1% rhinacanthin C) was confirmed non-genotoxic, non-skin corrosive, and non-irritating in both animal models and human patch tests. The ingredient is generally considered non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rhinacanthus nasutus Leaf Extract is a valuable botanical offering soothing, antioxidant, and antimicrobial benefits, with a strong safety profile confirmed in human studies, making it suitable for a wide range of skin types.

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