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Moumoujus

RHEUM RHABARBARUM STALK EXTRACT.

Valuable CAS 97435-16-0 / SKIN CONDITIONING

Rheum Rhabarbarum Stalk Extract is a botanical active renowned for its multifaceted benefits, including potent antioxidant and anti-inflammatory properties. It contributes to a more balanced and soothed complexion by reducing redness and promoting skin regeneration, suitable for diverse skin needs.

Summary

Antioxidant Skin-conditioning Anti-inflammatory Skin lightening Photoprotective Wound healing support Sebum control Antiseptic

Science

Mechanism of Action

This extract leverages its rich composition of anthraquinones, polyphenols, stilbenes, and organic acids to exert its biological activity. It inhibits COX-2 and inflammatory cytokines (TNF-α, IL-1α, α-MSH), providing significant anti-inflammatory benefits that soothe irritated skin and reduce redness. As a potent antioxidant, it effectively scavenges ABTS and hydroxyl radicals and demonstrates high ferrous ion chelating activity, protecting the skin from oxidative damage. Furthermore, studies indicate proangiogenic effects that support wound healing, while its inhibitory action on tyrosinase and tyrosine kinase suggests a potential for skin lightening and photoprotection. It also offers subtle moisturizing effects and can help regulate sebum production, alongside antiseptic properties.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Anti-inflammatory effects, including COX-2 inhibition, observed in human endothelial cells (HUVECs).
  2. 02 Promotes proangiogenic activity in HUVECs, stimulating angiogenesis to support incision healing.
  3. 03 Demonstrates ABTS radical scavenging activity, indicating significant antioxidant potential.
  4. 04 Exhibits hydroxyl radical inhibition activity, contributing to antioxidant defense.
  5. 05 Shows high chelating activity against ferrous ions, further bolstering antioxidant effects.

Transparency

Dusting Analysis

Not commonly dusted

Data not available to determine dusting metrics specific to cosmetic formulation percentages. Clinical studies report effective concentrations in µg/mL and mg/mL for in vitro and ex vivo applications.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 3.6
0 7 14

Stability

Rhubarb stalk extracts are generally stable in acidic formulations, aligning with the natural pH range of 3.0-3.6 for rhubarb stalks and juice. Extracts can be prepared with a variety of solvents including water, methanol, ethyl acetate, and hexane, indicating solubility across different polarities. The presence of natural preservatives like sorbic and benzoic acids contributes to its inherent stability.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has included Rheum Rhabarbarum Stalk Extract on its 2024 Final Priority List for assessment. While comprehensive cosmetic safety data is pending, rhubarb stalk is widely consumed as food and is considered 'possibly safe' for topical application. It is crucial to use only the stalk extract, as rhubarb leaves contain high levels of toxic oxalic acid.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rheum Rhabarbarum Stalk Extract offers valuable multi-functional benefits, including potent antioxidant and anti-inflammatory action, making it a promising ingredient for diverse precision skincare formulations, pending further in vivo clinical and CIR assessment.

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