Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RHEUM RHABARBARUM EXTRACT.

Valuable CAS 97435-16-0 / SKIN CONDITIONING

Rheum Rhabarbarum Extract is a botanical powerhouse recognized for its multifaceted benefits in skincare. It delivers potent antioxidant and anti-inflammatory actions, promoting skin regeneration and a more even complexion. The extract also contributes to hydration, oil balance, and overall skin resilience.

Summary

antioxidant anti-inflammatory skin-conditioning wound-healing moisturizing oil-control skin-lightening antiseptic cell-renewal

Science

Mechanism of Action

RHEUM RHABARBARUM EXTRACT operates as a robust antioxidant, actively defending the skin against free radical damage and mitigating the visible signs of aging. Its anti-inflammatory efficacy stems from inhibiting COX-2 enzyme activity and reducing the synthesis of prostaglandin E2, alongside suppressing pro-inflammatory cytokines such as IL-2 and TNF-α. The extract stimulates skin regeneration and cell renewal, which translates to improvements in skin elasticity, smoothness, and the appearance of fine lines. Rhaponticin, a key constituent, has been observed in in-vitro studies to foster the proliferation of skin cells and enhance skin barrier lipids. It provides a subtle moisturizing effect, supporting skin hydration, radiance, and softness. Furthermore, the extract assists in regulating skin oil secretion and exhibits a natural skin-lightening effect by modulating tyrosinase and tyrosine kinase activities and α-MSH production in melanocytes (noted in studies involving related Rheum species). Its inherent antiseptic properties also help in preventing bacterial proliferation and accelerating wound healing processes.

Research

Clinical Evidence

Medium confidence
Effective range 1–30%
Optimal

N/A

Key findings

  1. 01 In vitro studies utilizing human umbilical vein endothelial cells (HUVECs) demonstrated a significant reduction, approximately 80%, in Serpin E1/PAI-1 release at concentrations ranging from 1-30 µg/mL. Concentrations exceeding 30 µg/mL led to decreased cell viability in HUVECs.
  2. 02 Another in vitro study showed an inhibition of COX-2 enzyme activity with an IC50 of 19.44 µg/mL in HUVECs.
  3. 03 Peripheral blood mononuclear cells (PBMCs) treated with 1-50 µg/mL of the extract exhibited reduced synthesis of prostaglandin E2, decreased release of pro-inflammatory cytokines (IL-2 and TNF-α), and lowered metalloproteinase-9 levels.
  4. 04 In an in vivo context (concentration unspecified), the extract promoted incision healing by decreasing inflammatory cells like leukocytes and neutrophils, inhibiting bacterial growth, and stimulating faster growth of vascular endothelial cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6.5
0 7 14

Stability

For optimal stability, a commercial Rheum Rhabarbarum Extract (typically 20% extract dissolved in water and glycerin) is best formulated within a pH range of 4.0 to 6.5.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While generally well-tolerated, individuals with sensitivities to botanicals may experience allergic reactions, skin irritation, or redness. In vitro research highlighted decreased cell viability in HUVECs at concentrations exceeding 30 µg/mL, suggesting a need for careful formulation within effective, non-cytotoxic ranges.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Rheum Rhabarbarum Extract is a valuable botanical component, offering significant antioxidant and anti-inflammatory actions, promoting skin regeneration, and contributing to overall skin health and clarity.

Related

Similar Ingredients

Finding similar ingredients…