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Moumoujus

RH-POLYPEPTIDE-9.

Valuable CAS 127464-60-2 / NOT REPORTED

RH-Polypeptide-9 is a synthetic growth factor, a recombinant analog of human VEGFA, designed to significantly enhance skin's vitality. It actively promotes microcirculation, cellular rejuvenation, and collagen maintenance, leading to a smoother, firmer, and visibly healthier complexion.

Summary

Cell Communication Skin Conditioning Promotes Angiogenesis Enhances Microcirculation Supports Cellular Proliferation Aids Cellular Rejuvenation Maintains Collagen Production Reduces Oxidative Stress Anti-inflammatory Support Assists Wound Healing Improves Nutrient Delivery

Science

Mechanism of Action

As a cell-communicating protein, RH-POLYPEPTIDE-9 (sh-Polypeptide-9) specifically targets receptors on endothelial cells. This binding initiates angiogenesis, the critical process of new blood vessel formation, which in turn optimizes the delivery of vital nutrients and oxygen to the dermal layers. The peptide concurrently stimulates the production of proteins essential for cellular restructuring, supports fibroblast cell growth and migration, and aids the skin's natural healing processes. Furthermore, it contributes to collagen maintenance and reduces oxidative stress by lowering levels of pro-inflammatory interleukin-1α, thereby fostering comprehensive skin rejuvenation.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This growth factor is water-soluble. Its efficacy can be diminished in acidic environments; therefore, it is advised to apply products with AHAs or BHAs a few minutes prior to products containing RH-POLYPEPTIDE-9 to ensure optimal stability and absorption.

Conflicts

  • acidic environments (may destabilize)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While general peptides often exhibit a low sensitization risk, specific assessments by CIR, SCCS, or FDA for RH-POLYPEPTIDE-9 are currently unavailable. It is crucial to avoid use in individuals with psoriasis, as VEGFA activity can exacerbate the condition. Additionally, application on sunburned skin or after high-dose UV exposure is not recommended.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RH-POLYPEPTIDE-9 is a valuable growth factor for advanced anti-aging and skin rejuvenation, effectively boosting microcirculation and collagen, though specific clinical dosage data is currently limited.

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