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Moumoujus

RH-POLYPEPTIDE-7.

Insufficient Data CAS 12629-01-5 / HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

RH-POLYPEPTIDE-7 is a bio-engineered peptide, a synthetic analog of human growth hormone (hGH), designed to mimic its regenerative effects on skin. It functions as a cellular messenger, promoting skin cell renewal and enhancing the production of vital structural proteins like collagen and elastin.

Summary

Antiseborrhoeic Skin Protecting Humectant Skin Conditioning Skin Elasticity Enhancer Skin Firming Anti-aging Skin Barrier Strengthening Wrinkle Reduction Anti-inflammatory Breakout Clearing (potential)

Science

Mechanism of Action

This precision peptide operates by binding to growth hormone receptors (GHR) on dermal fibroblasts, thereby stimulating their proliferation. This action leads to increased production of insulin-like growth factor-1 (IGF-1) and its binding protein, IGFBP-3, which synergistically boost the synthesis of collagen and other extracellular matrix components. Beyond direct growth factor mimicry, RH-POLYPEPTIDE-7 signals the skin to strengthen its barrier, improve elasticity and firmness, reduce the appearance of wrinkles, and modulate inflammatory responses, contributing to overall skin health and conditioning.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

While RH-POLYPEPTIDE-7 demonstrates a compelling mechanism of action, specific concentration data for optimal efficacy in topical formulations is not widely available. Comprehensive human clinical studies to ascertain common dusting practices or effective inclusion rates are currently lacking.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Peptide stability and solubility are highly sensitive to pH; meticulous monitoring of the final solution's pH is critical to prevent degradation or precipitation.

Conflicts

  • Alpha hydroxy acids (AHAs) may reduce the efficacy of peptides through potential degradation.
  • Combining peptides with other active ingredients warrants caution, as it may alter their safety parameters or effectiveness.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Specific, comprehensive safety assessments for RH-POLYPEPTIDE-7 by regulatory bodies such as CIR, SCCS, or FDA are not readily available. The CIR panel has indicated that peptides, in general, are safe for topical use at concentrations below 10 parts per million (ppm), noting this assessment is for single-ingredient use. Paula's Choice lists RH-POLYPEPTIDE-7 as 'Not rated,' signifying that research is under review.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

RH-POLYPEPTIDE-7 offers a compelling biological mechanism for skin regeneration and anti-aging, but the absence of specific clinical efficacy data and comprehensive safety assessments necessitates further research and careful formulation.

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