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Moumoujus

RH-POLYPEPTIDE-69.

Valuable / SKIN CONDITIONING

RH-POLYPEPTIDE-69 is a cutting-edge recombinant collagen type III, genetically engineered to be fully identical to human skin's natural collagen sequence. This biomimetic peptide acts as a vegan structural component, actively stimulating collagen production and safeguarding against its degradation, leading to visibly stronger, more elastic, and hydrated skin.

Summary

Humectant Skin Conditioning Skin Protecting

Science

Mechanism of Action

Functioning as a skin-identical biomimetic collagen, RH-POLYPEPTIDE-69 directly targets the skin's extracellular matrix. Its dual-action mechanism involves significantly boosting the synthesis of endogenous collagen types I and III, essential for skin's structural integrity. Concurrently, it inhibits key enzymatic pathways, specifically collagenase and various metalloproteinases (MMPs), which are responsible for breaking down collagen. This precise intervention fortifies the dermal-epidermal junction, enhancing skin elasticity, significantly improving hydration levels, and visibly reducing the depth of wrinkles. It also provides a protective barrier against environmental aggressors.

Research

Clinical Evidence

Medium confidence
Effective range 2.5–10%
Optimal

N/A

Key findings

  1. 01 Clinical research, supported by in vitro and ex vivo studies, demonstrates that RH-POLYPEPTIDE-69, when applied at concentrations between 2.5% and 10%, markedly improves skin architecture. It achieves this by stimulating the synthesis of both collagen type I and type III, while simultaneously reducing collagen degradation through the inhibition of collagenase and matrix metalloproteinases. This leads to enhanced skin elasticity, improved hydration, and a strengthened skin structure.

Transparency

Dusting Analysis

Not commonly dusted

RH-POLYPEPTIDE-69 is an active ingredient with specific studied efficacy at concentrations between 2.5% and 10% in product formulations. Its active substance content is approximately 2% in its liquid raw form, indicating that it is designed for use at concentrations where it can exert its biomimetic effects, rather than being used at sub-efficacious levels.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The active substance typically constitutes approximately 2% of the liquid raw material. Ongoing research focuses on optimizing its bioavailability and stability, with advanced delivery systems like liposomes and nanoemulsions being explored to maximize its effectiveness and ensure sustained benefits.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed RH-POLYPEPTIDE-69, they have broadly affirmed the safety of many tissue-derived proteins and peptides in cosmetic applications. Manufacturers report good safety and efficacy, with non-animal testing showing no indications of allergy risks, skin irritation, or eye irritation. Furthermore, a related recombinant Type III small molecule collagen, 'sr-(sh-Polypeptide -69 Dipeptide-19)', has received official INCI catalog approval, supporting its safety and efficacy profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RH-POLYPEPTIDE-69 is a valuable biomimetic ingredient that effectively strengthens skin structure, enhances elasticity, and improves hydration by precisely regulating collagen synthesis and degradation.

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