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Rh-polypeptide-6

RH-POLYPEPTIDE-6 is a synthetic recombinant peptide that functions as an analog of human Interleukin 10 (IL-10), delivering potent anti-inflammatory and soothing effects. It is particularly beneficial for mitigating irritation and allergic skin reactions, with demonstrated potential in preventing scar tissue formation.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Skin conditioning Anti-inflammatory Soothing

Science

Mechanism of Action

This synthetic recombinant single-chain peptide mimics human Interleukin 10 (IL-10), a key anti-inflammatory cytokine, to regulate the immune response and antibody production. Acting as an anti-histamine and immunosuppressive agent, RH-POLYPEPTIDE-6 alleviates itching and burning, reduces scratching, and inhibits autoimmune reactions. Additionally, it downregulates collagen type I production, contributing to the prevention of scar tissue during wound healing.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical observations suggest RH-POLYPEPTPE-6 alleviates itching and burning sensations caused by allergens. It has shown efficacy in cases of psoriasis and in normalizing an overactive immune system that produces excess immune cells. Furthermore, it helps prevent scar tissue formation during wound healing and is indicated as a potential treatment for keloid scarring.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While specific optimal pH for stability is not detailed for RH-POLYPEPTIDE-6, peptides generally exhibit pH-dependent stability and activity.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

RH-POLYPEPTIDE-6 is described as a safe, soothing ingredient for reactive or sensitive skin. Although the Cosmetic Ingredient Review (CIR) Expert Panel has assessed general categories of proteins and peptides as safe for cosmetic use, specific CIR or SCCS review data for RH-POLYPEPTIDE-6 is currently unavailable. The FDA does not pre-approve cosmetic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RH-POLYPEPTIDE-6 is a valuable ingredient due to its powerful anti-inflammatory and soothing properties, making it highly effective for calming irritated and reactive skin, and showing promise in scar prevention.

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