Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RH-POLYPEPTIDE-47.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

RH-POLYPEPTIDE-47 is a synthetic peptide engineered to mimic human collagen type 1, a critical protein for maintaining skin's structural integrity. It functions as a potent skin conditioning agent, actively supporting the extracellular matrix to enhance firmness and elasticity while reducing the appearance of lines and wrinkles.

Summary

Skin conditioning Anti-aging Firming Collagen boosting Moisturizing Barrier support Cell proliferation

Science

Mechanism of Action

This peptide operates by signaling the skin to activate its natural repair mechanisms, mirroring the actions of endogenous collagen fragments. It promotes the proliferation of human dermal fibroblasts (HDFs), crucial cells responsible for collagen production, and increases levels of key proteins like collagen I, P4HA1, α-SMA, and TGF-β1. This comprehensive action leads to improved fibroblast contractility, enhanced collagen synthesis, strengthened skin barrier function, and protection against environmental stressors, ultimately boosting skin elasticity and mitigating visible signs of aging.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–5%
Optimal

5%

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

While specific dusting thresholds are not provided, clinical studies indicate efficacy starting at 0.5% for cell proliferation, and general use levels typically range from 0.1% to 1%. Concentrations below 0.1% might not deliver optimal benefits, but the available data does not suggest it is commonly 'dusted' at ineffective levels in reputable formulations, as even 0.1% is a recognized use level in blends.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

Peptides generally exhibit optimal dissolution and stability within a near-neutral pH range (6.0-8.0) due to their charge profiles. RH-POLYPEPTIDE-47 is typically found in water-based formulations, indicating good water solubility. Glycosylation can further enhance peptide stability in aqueous solutions. Formulation in water-in-oil systems may be achievable with appropriate emulsifiers.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

RH-POLYPEPTIDE-47 (also known as Nicotiana Benthamiana Hexapeptide-40 SH-Polypeptide-47) is broadly considered safe for topical application in cosmetic products. While a specific individual safety assessment by CIR, SCCS, or FDA is not publicly available, peptides generally have a strong safety record, are well-tolerated across skin types, and exhibit low invasiveness. Potential side effects such as skin irritation, redness, or allergic reactions are minimal, though a patch test is always prudent. Data regarding its topical use during pregnancy and breastfeeding are currently insufficient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

RH-POLYPEPTIDE-47 is a valuable anti-aging peptide that robustly supports skin's natural repair mechanisms, enhances collagen production, and improves firmness and elasticity across all skin types.

Related

Similar Ingredients

Finding similar ingredients…