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Moumoujus

RH-POLYPEPTIDE-4.

Insufficient Data CAS - / SKIN CONDITIONING

RH-Polypeptide-4 is a synthetic analog of human Stem Cell Factor (SCF), functioning as a cytokine to promote cellular repair and tissue regeneration. It is recognized for its potential in both skin and hair care, specifically for its proposed role in repigmentation and stimulating hair growth.

Summary

antioxidant hair conditioning skin conditioning

Science

Mechanism of Action

As a synthetic recombinant analog of human Stem Cell Factor (SCF), RH-Polypeptide-4 operates as a cytokine, regulating the survival, proliferation, and differentiation of hematopoietic stem cells. It actively contributes to the healing process by activating hematopoietic precursor cells, thereby facilitating cellular and tissue repair. Its detection in human keratinocytes and along melanocyte migration pathways suggests chemotactic and mitogen effects on melanocytes, indicating its potential as a repigmenting agent for both skin and hair. Furthermore, when combined with other cytokines, RH-Polypeptide-4 can accelerate the recovery from granulation sphere decline, enhancing the efficiency of hematopoietic cells and keratinocytes and improving nutrient delivery.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In cases of Androgenetic alopecia, hair follicle cells demonstrated 66% less Stem Cell Factor (SCF) secretion compared to non-balding cells. RH-Polypeptide-4 (sh-Polypeptide-4) has been shown to support hair growth by enhancing the movement and differentiation of melanin generation factors and stimulating the creation of hair growth factors.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptide stability and solubility are influenced by pH; monitoring the final solution's pH is crucial to prevent precipitation or degradation. Reconstituted peptides typically benefit from refrigeration or freezing to maintain their integrity.

Synergies

  • Other cytokines (to enhance cellular efficiency)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety reviews for RH-POLYPEPTIDE-4 (sh-Polypeptide-4) by regulatory bodies such as CIR, SCCS, or FDA are not currently available. General safety assessments exist for broader categories of peptides and hydrolyzed proteins, but detailed data specific to this ingredient is lacking.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

RH-Polypeptide-4 demonstrates promising cellular repair, repigmentation, and hair growth potential through its cytokine action; however, more comprehensive clinical and safety data are required to establish its definitive role in precision skincare formulations.

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