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Moumoujus

RH-POLYPEPTIDE-31.

Avoid / ANTIMICROBIAL, SKIN PROTECTING

RH-POLYPEPTIDE-31, currently designated as sh-Polypeptide-31, is a synthetic recombinant peptide designed to mimic human Insulin-like Growth Factor-2 (IGF-2). It aims to enhance skin density, tighten the skin, and visibly reduce the appearance of wrinkles through its potent cellular activities.

Summary

skin conditioning anti-aging firming collagen boosting skin thickening

Science

Mechanism of Action

This synthetic recombinant peptide precisely mimics human Insulin-like Growth Factor-2 (IGF-2), engaging specific skin cell membrane receptors to exert an insulin-like effect. It actively stimulates the proliferation and migration of dermal fibroblasts, significantly boosting the natural production of collagen. This comprehensive action facilitates the dynamic restoration of all skin layers, reinforcing intercellular connections and consequently thickening the skin's overall structure.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Reported to reduce wrinkles, increase skin density, and tighten the skin when incorporated into skincare formulations.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that RH-POLYPEPTIDE-31 is commonly dusted or used at ineffective concentrations in formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a peptide, sh-Polypeptide-31's stability in aqueous solutions is critically dependent on environmental factors. It is susceptible to various chemical degradation pathways, including oxidation, hydrolysis, and deamidation, as well as physical degradation leading to aggregation or precipitation. pH is a paramount parameter influencing the peptide's stability and efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Due to its potent mitogen and growth factor-mimicking properties, RH-POLYPEPTIDE-31 presents significant safety considerations. Research indicates a correlation between the overexpression of Insulin-like Growth Factor-2 (IGF-2)—which this peptide mimics—and the formation of hypertrophic scars in damaged skin, as well as a potential link to tumor progression. Consequently, its use requires strict adherence to product instructions or professional medical consultation. The ingredient's safety status has not been reviewed by the Cosmetic Ingredient Review (CIR).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

This ingredient is not recommended due to significant unaddressed safety concerns related to its growth factor-mimicking activity, including potential links to hypertrophic scarring and tumor progression, coupled with a 'not reviewed' CIR status.

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