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Moumoujus

RH-POLYPEPTIDE-22.

Avoid CAS 98726-64-8 / SKIN CONDITIONING

RH-POLYPEPTIDE-22 is a synthetic recombinant human transforming growth factor beta 1 (TGFβ-1) analog peptide, composed of 113 amino acids. It is engineered to stimulate cellular regeneration, enhance the synthesis of critical structural proteins like collagen and elastin, and modulate skin pigmentation. Its multifaceted action targets wound healing, skin firmness, and brightening.

Summary

Cellular Regeneration Collagen Synthesis Elastin Synthesis Fibronectin Synthesis Skin Brightening Anti-inflammatory Microcirculation Improvement Wound Healing Support Skin Conditioning

Science

Mechanism of Action

This peptide functions by directly stimulating the proliferation and differentiation of epithelial cells and fibroblasts, processes fundamental for effective wound healing. It acts as a powerful catalyst for the synthesis of collagen, elastin, and fibronectin, essential components for skin structure and elasticity. Furthermore, RH-POLYPEPTIDE-22 promotes microvascular cell renewal, leading to improved microcirculation within the skin. It also inhibits tyrosinase activity, thereby reducing melanin production and contributing to a skin brightening effect. The ingredient exhibits anti-inflammatory properties through the suppression of pro-inflammatory cytokines and can regulate immune responses, potentially mitigating autoimmune processes.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While water-soluble, RH-POLYPEPTIDE-22 may present aesthetic or stability challenges that could limit its utility in formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

RH-POLYPEPTIDE-22 is currently regulated and prohibited for use in cosmetics within Europe. Although general peptides have been reviewed by CIR, with some deemed safe for topical use at concentrations below 10 ppm, the safety status of this specific ingredient has not been individually confirmed. General data suggests a likelihood of irritation, which may be exacerbated when combined with other potentially problematic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its promising biochemical actions, the regulatory prohibition in Europe and unconfirmed safety profile necessitate avoidance for precision skincare formulations.

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