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Moumoujus

RH-POLYPEPTIDE-2.

Avoid CAS 52500-60-4 / SKIN CONDITIONING

RH-POLYPEPTIDE-2, also known as sh-Polypeptide-2, is a synthetic peptide engineered as an analog of human Thioredoxin. It is designed to stimulate skin cell regeneration, significantly boost collagen synthesis, and provide potent antioxidant protection, leading to a visibly revitalized and brighter complexion.

Summary

Antioxidant Skin-identical ingredient Cell-communicating ingredient Skin conditioning

Science

Mechanism of Action

As a synthetic analog of human Thioredoxin (TRX), RH-POLYPEPTIDE-2 functions by promoting dermal cell growth and proliferation. It delivers powerful antioxidant benefits, actively reducing free radicals and preventing programmed cell death, thereby enhancing the skin's natural defense mechanisms. This polypeptide also facilitates correct protein structure formation via disulfide bonds and modulates transcriptional factors to improve dermal cell organization, resulting in a firmer, more even-toned appearance. Furthermore, it stimulates new skin cell generation, effectively diminishing existing lines and wrinkles, preventing future wrinkle formation, and contributing to melanin and collagen synthesis regulation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Peptides like RH-POLYPEPTIDE-2 are prone to degradation through hydrolysis, deamidation, and oxidation. Stability is compromised by elevated temperatures, high humidity, and moisture, particularly in powder forms. Crystalline excipients can also diminish long-term stability. Its poor membrane permeability necessitates advanced delivery systems, such as nano-systems. Stability can be improved with buffers, sugars (e.g., trehalose, mannitol), and antioxidants (e.g., ascorbic acid).

Conflicts

  • crystalline excipients
  • extreme pH deviations (especially alkaline pH, and pH above 7 which promotes oxidation)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

RH-POLYPEPTIDE-2 is explicitly classified as 'Regulated, Forbidden in Europe.' While broader categories of peptides have general safety assessments, this specific ingredient has not undergone a dedicated review by the Cosmetic Ingredient Review (CIR).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite exhibiting promising anti-aging and antioxidant benefits, the classification of RH-POLYPEPTIDE-2 as 'Regulated, Forbidden in Europe' makes its use highly problematic and therefore not recommended for a globally compliant brand.

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