Science
Mechanism of Action
Derived from a synthesized copy of the human gene encoding nerve growth factor beta, RH-POLYPEPTIDE-14 is hypothesized to function by modulating cellular proliferation and differentiation. These fundamental biological processes are crucial for skin cell renewal and maintaining overall dermal health.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The specific optimal pH range for RH-POLYPEPTIDE-14 is unknown. Peptide stability and solubility are generally pH-dependent, and maintaining a controlled solution pH is critical to prevent degradation or precipitation. Certain beta-peptides have demonstrated reduced stability at higher pH levels (e.g., 7.4-9.6) with less impact at lower pH (e.g., 7.4-1.8), suggesting pH-induced conformational changes can occur.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) panel generally advises that peptides are safe for topical use at concentrations below 10 parts per million (ppm). However, RH-POLYPEPTIDE-14 (or sh-polypeptide-14) has not undergone a specific safety assessment by CIR, SCCS, or FDA. The CIR also cautioned that safety parameters might vary when peptides are combined with other ingredients or applied to damaged skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While theoretically offering benefits related to skin cell renewal and conditioning based on its derivation, comprehensive direct clinical and safety data for RH-POLYPEPTIDE-14 are currently insufficient to ascertain its precise efficacy and optimal use in topical formulations.
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