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Moumoujus

RH-POLYPEPTIDE-13.

Valuable CAS - / SKIN CONDITIONING

RH-POLYPEPTIDE-13, also identified as sh-Polypeptide-13 or CG-Noggin, is a precision-engineered bioactive peptide designed to stimulate cellular regeneration. It actively promotes hair placode formation, contributing to hair follicle development, and significantly enhances both epidermal thickness and cell proliferation.

Summary

Skin Conditioning Hair Growth Promotes Hair Follicle Development Enhances Epidermal Thickness Increases Cell Proliferation

Science

Mechanism of Action

This polypeptide operates by antagonizing Bone Morphogenetic Protein 4 (BMP4), a key signaling protein that typically inhibits hair follicle development. By neutralizing BMP4's suppressive effects, RH-POLYPEPTIDE-13 actively stimulates the formation of new hair placodes. Additionally, it significantly upregulates cell proliferation and contributes to increased epidermal thickness within the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While a specific optimal pH range for stability is not provided, RH-POLYPEPTIDE-13 is water-soluble. As with many larger peptides, optimizing penetration through the stratum corneum can be a challenge; therefore, advanced delivery systems like liposomes may be employed to enhance deeper skin layer absorption.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

RH-POLYPEPTIDE-13 is broadly described as a safe and effective ingredient. However, specific safety reviews or established maximum concentration limits by regulatory bodies such as CIR, SCCS, or FDA were not identified in the provided data. General compliance with EU cosmetic safety and efficacy requirements is expected.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RH-POLYPEPTIDE-13 is a valuable ingredient for targeted hair growth and epidermal regeneration due to its clear mechanism of action, though comprehensive quantitative clinical data and broad skin compatibility information are currently limited.

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