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Moumoujus

RH-POLYPEPTIDE-11.

Valuable CAS 62031-54-3 / SKIN CONDITIONING

RH-POLYPEPTIDE-11, also known as Acidic Fibroblast Growth Factor (aFGF or FGF1), is a potent cell-communicating peptide integral to skin regeneration and cellular vitality. It actively stimulates fibroblast proliferation, significantly boosting the synthesis of essential structural proteins, and provides robust antioxidant protection against cellular aging.

Summary

Cell-communicating Promotes cell proliferation Enhances collagen synthesis Enhances elastin synthesis Supports skin regeneration Accelerates wound healing Antioxidant protection Promotes hair growth Improves microcirculation Stimulates fibroblast activity Stimulates keratinocyte activity

Science

Mechanism of Action

Functioning as a key cell-communicating ingredient, RH-POLYPEPTIDE-11 binds to specific receptors on fibroblasts, initiating a cascade of cellular events that promote cell proliferation and tissue regeneration. This action directly enhances collagen and elastin synthesis, crucial for maintaining skin structure and elasticity. Furthermore, it exhibits potent antioxidant properties, reducing free radicals and inhibiting the aging process of skin cells. When delivered through advanced carrier systems, such as liposomes, it can penetrate the stratum corneum to stimulate both fibroblast and keratinocyte proliferation in deeper skin layers. Its biological activity also extends to promoting primary hair cell proliferation for hair growth and improving vascularization through enhanced blood vessel endothelial cell proliferation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptides, including RH-POLYPEPTIDE-11, are susceptible to destabilization in highly acidic environments, which can reduce their biological activity. While a precise optimal pH range for this specific polypeptide remains unconfirmed, maintaining a balanced pH is crucial for preserving its efficacy.

Conflicts

  • Strong acidic ingredients (e.g., AHAs, BHAs) which may destabilize growth factors and reduce their efficacy. It is recommended to apply acidic products first and wait a few minutes before layering growth factor products.

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Unknown

RH-POLYPEPTIDE-11 is generally regarded as a safe, effective, and skin-compatible ingredient. However, a specific Cosmetic Ingredient Review (CIR) Panel safety assessment, including a defined 'safe as used' maximum concentration for this particular polypeptide, is not available in the public domain. General guidelines for peptides suggest safety for topical use at concentrations less than 10 parts per million (ppm), but this is not specific to RH-POLYPEPTIDE-11.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

RH-POLYPEPTIDE-11 offers comprehensive regenerative, anti-aging, and protective benefits for skin and hair, though precise concentration data for optimal efficacy and safety is currently limited.

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