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Moumoujus

RH-POLYPEPTIDE-1.

Avoid CAS - / SKIN CONDITIONING, SKIN PROTECTING

RH-POLYPEPTIDE-1 is a single-chain recombinant human peptide designed as a potent cell-communicating ingredient. It functions by stimulating fibroblast activity and promoting the synthesis of essential skin components like collagen and hyaluronic acid, leading to significant skin rejuvenation and improved elasticity.

Summary

Cell-communicating ingredient Skin conditioning Collagen booster Elasticity enhancer Anti-aging Skin regeneration Hyaluronic acid production booster Oxidative damage reduction

Science

Mechanism of Action

Derived from the gene coding for Basic Fibroblast Growth Factor (bFGF or FGF-2), RH-POLYPEPTIDE-1 operates by directly stimulating the growth and proliferation of dermal fibroblasts. This action significantly boosts the synthesis of collagen and other extracellular matrix components, which are crucial for maintaining skin structure and reducing the appearance of wrinkles. Furthermore, it plays a role in regulating blood vessel development to enhance nutrient delivery to epidermal cells, supporting their growth and differentiation. The peptide also interacts synergistically with Epidermal Growth Factor (EGF) and Insulin-like Growth Factor-1 (IGF-1), amplifying the skin's natural production of hyaluronic acid for a smoother, healthier complexion. Its potential for melanocyte migration and re-pigmentation also suggests broader regenerative capabilities.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–5%
Optimal

5%

Transparency

Dusting Analysis

Not commonly dusted

There is insufficient data available to determine if RH-POLYPEPTIDE-1 is commonly 'dusted' or to establish specific dusting thresholds in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a peptide, RH-POLYPEPTIDE-1 exhibits pH-dependent stability and solubility. Deamidation rates are known to increase under alkaline conditions, and oxidation accelerates when the pH exceeds 7. For optimal formulation, meticulous reconstitution from lyophilized powder is essential to ensure complete dissolution without aggregation or degradation. Given its relatively large molecular size, effective topical application and enhanced stability often require encapsulation within advanced delivery systems, such as liposomes or PLGA-coated nanoparticles.

Synergies

  • Hyaluronic Acid (boosted production, often co-formulated)
  • Carboxymethyl Cellulose (co-formulated in clinical study)
  • Epidermal Growth Factor (EGF) (interacts to boost HA production)
  • Insulin-like Growth Factor-1 (IGF-1) (interacts to boost HA production)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While safety and toxicity studies for topical SH-Polypeptide-1 (a synonym for RH-POLYPEPTIDE-1) have indicated low irritation and no significant adverse effects, its regulatory status presents a critical consideration. RH-POLYPEPTIDE-1 is listed in CosIng under Annex II/416 of the EU Cosmetics Regulation, which prohibits 'Cells, tissues or products of human origin' in cosmetic products. Consequently, EWG Skin Deep rates 'Rh Polypeptide 1' as 'Unacceptable' for EWG VERIFIED products. Although personal concerns such as cancer, allergies, and developmental toxicity are rated 'LOW', its classification as a product of human origin poses a substantial regulatory impediment for cosmetic product development in key markets.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Avoid

Despite demonstrating promising in-vitro efficacy for skin rejuvenation and exhibiting low topical irritation, RH-POLYPEPTIDE-1's explicit prohibition under EU cosmetics regulations due to its human origin classification renders it unsuitable for compliant product development in many global markets.

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