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RH-OLIGOPEPTIDE-4.

Valuable CAS - / SKIN CONDITIONING

RH-Oligopeptide-4, also known as sh-Oligopeptide-4 or Oligopeptide-4, is a synthetic recombinant Thymosin-β4 peptide engineered to significantly enhance skin health. It targets primary concerns of aging by improving elasticity, visibly reducing wrinkles, and boosting hydration, while simultaneously addressing dark spots and acne. This multifunctional peptide promotes overall skin regeneration and resilience.

Summary

Antioxidant Anti-aging Skin elasticity improvement Wrinkle reduction Collagen synthesis stimulation Elastin synthesis stimulation Skin regeneration Photoprotection Wound healing Hydration Anti-acne Dark spot reduction

Science

Mechanism of Action

RH-Oligopeptide-4 operates through several interconnected mechanisms. It functions as a potent antioxidant by actively clearing reactive oxygen species (ROS) and ABTS free radicals, markedly increasing superoxide dismutase (SOD) activity. The peptide optimizes mitochondrial function, maintaining membrane potential and elevating ATP levels to boost cellular energy. Furthermore, it stimulates the production of vital extracellular matrix (ECM) components like collagen (COL1 and COL3) and elastin, while concurrently reducing matrix metalloproteinase (MMP) activity. This comprehensive action combats UVA-induced collagen degradation, mitigates photoaging effects, and accelerates skin repair by promoting cellular proliferation, migration, and collagen deposition within damaged tissues.

Research

Clinical Evidence

Medium confidence
Effective range 0.002–0.01%
Optimal

N/A

Key findings

  1. 01 In a study utilizing a raw material blend containing Oligopeptide-4, the active peptide, at concentrations between 0.002% and 0.01% in the final product, demonstrated significant efficacy. It effectively removes free radicals, enhances mitochondrial function, increases cellular energy, and exhibits excellent anti-oxidative stress, anti-wrinkle, and firming effects. The peptide combats collagen loss induced by UVA radiation, stimulates ECM regeneration, resists photoaging, and restores cellular proliferation and migration abilities.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.002%
Red flag below
0.001%

While clinically effective within a concentration range of 0.002% to 0.01% of the active peptide, formulations containing less than 0.002% RH-Oligopeptide-4 may offer diminished benefits, indicating potential 'dusting' where an insufficient amount is used for meaningful impact.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal stability, RH-Oligopeptide-4 should be incorporated into formulations at temperatures below 40°C. Raw material storage requires temperatures between 2-8°C, sealed and protected from light. For extended preservation, storage below -15°C to -20°C in an air-proofed container is recommended.

Conflicts

  • strong acids
  • strong bases
  • protein denaturants

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

EWG's Skin Deep database classifies Oligopeptide-4 with low concerns across categories including cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and general use restrictions, indicating a favorable safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

RH-Oligopeptide-4 is a highly valuable peptide, demonstrating multi-faceted anti-aging and regenerative properties through antioxidant action, mitochondrial enhancement, and ECM stimulation, suitable for diverse skin types and various advanced skincare applications.

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