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Moumoujus

RESEDA LUTEOLA EXTRACT.

Valuable CAS 90106-16-4 / SKIN CONDITIONING, SOOTHING

Reseda Luteola Extract, derived from the mignonette plant, is a botanical powerhouse rich in flavonoids like luteolin and apigenin. It offers multifunctional benefits including significant anti-inflammatory, antioxidant, and skin-brightening properties, making it a promising ingredient for comprehensive skin health.

Summary

Antioxidant Skin-Conditioning Agent Anti-inflammatory Skin Brightening UV Protection

Science

Mechanism of Action

This extract primarily operates through its active flavonoid compounds, notably luteolin and apigenin. Luteolin exerts anti-inflammatory effects by modulating the MAPK pathway, effectively decreasing UVB-induced erythema and inhibiting inflammatory mediators like cyclooxygenase-2 and prostaglandin E₂ production. It also functions as a potent antioxidant, neutralizing free radicals and offering DNA protection. Furthermore, its ability to chelate copper at the active site of the tyrosinase enzyme contributes to its skin-whitening capabilities.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

2.5%

Key findings

  1. 01 A 2.5% nanoparticular solubilisate of a luteolin-rich extract was clinically shown to dose-dependently reduce UVB-induced erythema in vivo, demonstrating efficacy comparable to 1% hydrocortisone. This formulation also exhibited excellent skin tolerance without irritation under occlusive application on non-irradiated skin.
  2. 02 In vitro bioassays revealed that Reseda luteola extract significantly inhibited melanin production (42% whitening activity), reduced inflammation (54%), and demonstrated strong antioxidant capacity (67%).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH ≥3
0 7 14

Stability

The flavonoid components within the extract, particularly luteolin, exhibit enhanced stability at approximately pH 3. The extract itself shows good solubility in polar solvents, being readily extracted with water (especially at alkaline pH) or methanol-water mixtures.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While formal safety assessments by CIR or SCCS are not yet available, a clinical study utilizing a 2.5% solubilized extract demonstrated excellent skin tolerance and no irritation, even under occlusive conditions. Comprehensive toxicological studies are still recommended for broader cosmetic application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Reseda Luteola Extract is a valuable botanical ingredient offering robust anti-inflammatory, antioxidant, and skin-brightening benefits, with demonstrated good skin tolerance at 2.5%, though further comprehensive safety data is still pending.

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