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Moumoujus

RESACETOPHENONE.

Avoid CAS 89-84-9 / ANTIOXIDANT, BLEACHING, SKIN CONDITIONING

Resacetophenone is an active ingredient recognized for its antioxidant, skin conditioning, and bleaching capabilities. It exhibits exceptional chemical stability across a wide pH range (3-12), making it versatile for diverse product formulations. However, its significant potential for skin irritation and sensitization necessitates careful consideration for dermal application.

Summary

Antioxidant Bleaching Skin Conditioning

Science

Mechanism of Action

Resacetophenone functions as a potent antioxidant, actively preventing the oxidative deterioration of cosmetic ingredients and potentially mitigating oxidative stress on the skin. Furthermore, it operates as a skin conditioning agent to help maintain skin health and possesses bleaching properties capable of lightening skin or hair pigmentation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted
Red flag below
0.1%

While the CIR panel assessed Hydroxyacetophenone (which includes Resacetophenone) as safe up to 5%, specific studies indicate Resacetophenone can cause allergic contact dermatitis at concentrations as low as 0.1% and 1%. Given the lack of robust clinical efficacy data for its purported benefits at concentrations proven universally safe, its inclusion in formulations could be considered for its claims rather than for proven, broad-spectrum skin benefits, raising a 'dusting' concern for precision skincare.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 12
0 7 14

Stability

Resacetophenone demonstrates remarkable chemical stability across a wide pH range, specifically between 3 and 12, without significant degradation. It is stable at room temperature in closed containers under normal storage and handling conditions, allowing for its effective use in both acidic and strongly alkaline products.

Conflicts

  • Oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk High

While the Cosmetic Ingredient Review (CIR) Expert Panel deemed Hydroxyacetophenone, which encompasses Resacetophenone, safe for cosmetic use up to 5%, pure Resacetophenone is distinctly characterized as a known irritant and skin sensitizer. Clinical patch tests demonstrated allergic contact dermatitis reactions in individuals at concentrations of 0.1% and 1%. Material Safety Data Sheet (MSDS) information further substantiates its capacity to cause skin and eye irritation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its broad pH stability and purported antioxidant and conditioning functions, Resacetophenone presents a high risk of skin irritation and allergic sensitization, making its use in precision skincare problematic.

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