Science
Mechanism of Action
This extract functions as a potent antioxidant, effectively neutralizing reactive oxygen species (ROS) and limiting the formation of advanced glycation end products (AGEs), thereby shielding skin cells from oxidative stress. Its anti-inflammatory capabilities soothe irritation, while specific constituents like verbascoside contribute antimicrobial and photoprotective benefits. The extract deeply moisturizes, aids in collagen synthesis, strengthens the skin's protective barrier, and fosters skin regeneration. Furthermore, it exhibits anti-tyrosinase activity, significantly inhibiting melanin production for skin brightening, and may improve microcirculation while demonstrating immunomodulatory effects.
Research
Clinical Evidence
Medium confidence0.1% (in-vitro for melanin inhibition)
Key findings
- 01 Oral supplementation with 100 mg/day of Rehmannia glutinosa leaf extract for 56 days reduced acne severity by 21.72% on day 28 and improved skin hydration and quality of life in females with moderate to severe acne, with no reported safety concerns.
- 02 In an in-vitro experiment, Rehmannia glutinosa root extract at a concentration of 0.1% (1mg/ml) demonstrated over 70% inhibition of melanin formation via anti-tyrosinase activity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While generally considered non-irritating, potential aesthetic or stability challenges may limit its versatility in certain formulations, necessitating careful evaluation during product development.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not yet evaluated this ingredient. However, an oral study using Rehmannia glutinosa leaf extract at 100 mg/day reported no safety or tolerability concerns. EWG Skin Deep identifies low concerns regarding cancer, allergies, and immunotoxicity for the ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Rehmannia Glutinosa Root Extract is a valuable botanical ingredient, offering a comprehensive array of benefits from antioxidant protection and anti-inflammatory action to skin brightening and hydration.
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