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Moumoujus

RAUWOLFIA SERPENTINA EXTRACT.

Insufficient Data CAS 90106-13-1 / ASTRINGENT, SKIN CONDITIONING

Rauwolfia Serpentina Extract is derived from the plant traditionally recognized for its diverse pharmacological properties. Preliminary research indicates its potential for antibacterial and antioxidant benefits, attributed to a rich composition of phytochemicals like indole alkaloids and flavonoids. Further dedicated cosmetic investigations are required to ascertain its precise efficacy and safety for topical applications.

Summary

Antioxidant Antibacterial Anti-inflammatory Antiproliferative

Science

Mechanism of Action

This extract operates through multiple pathways to potentially benefit the skin. Its antioxidant activity is primarily driven by free radical scavenging, which helps mitigate oxidative stress. It also exhibits anti-inflammatory properties, aiming to reduce skin irritation, and possesses antimicrobial effects, including both antibacterial and antifungal actions. Additionally, the extract has shown antiproliferative characteristics, suggesting potential in managing cellular growth. These actions are supported by its complex profile of phytochemicals, particularly indole alkaloids and flavonoids.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data is available to suggest this ingredient is commonly 'dusted' or overhyped in the cosmetic industry without sufficient evidence.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The extract exhibits poor water solubility, which presents a significant formulation challenge. To enhance dissolution rate and bioavailability, specialized techniques such as nanosuspension preparation may be required. It demonstrates solubility in various organic solvents, including ethanol, methanol, and ethyl acetate.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific cosmetic safety assessments from CIR, SCCS, or FDA have been identified. Traditional medicinal use of Rauwolfia serpentina internally has been associated with significant side effects such as gastrointestinal disturbances, depression, sexual dysfunction, and potential psychiatric symptoms, especially with overdose. While acute oral toxicity tests in mice with methanolic extract showed no acutely toxic signs at 100-400 mg/kg, these findings relate to internal ingestion and may not directly translate to topical cosmetic safety. Further comprehensive pharmacological and toxicological investigations are recommended to establish safety specifically for external, cosmetic applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Rauwolfia Serpentina Extract demonstrates promising in vitro antibacterial and antioxidant activities, but its overall rating is 'insufficient-data' due to the critical lack of specific cosmetic safety assessments and in vivo efficacy studies for topical skin application.

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