Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

RAUVOLFIA SERPENTINA ROOT EXTRACT.

Questionable CAS 90106-13-1 / SKIN CONDITIONING

Rauvolfia Serpentina Root Extract is a botanical ingredient recognized for its multifaceted properties, including antioxidant, anti-inflammatory, antibacterial, and astringent effects, largely attributed to its complex phytochemical profile. While preclinical studies suggest potential for skin benefits, its topical safety in cosmetic applications remains unassessed by major regulatory bodies, warranting careful consideration for precision formulations.

Summary

Antioxidant Anti-inflammatory Antibacterial Antifungal Astringent Skin conditioning Wound healing (potential)

Science

Mechanism of Action

This extract operates through a diverse array of bioactive compounds. Its antioxidant capacity, stemming from flavonoids and phenolics, actively neutralizes free radicals. Anti-inflammatory actions are similarly derived from these antioxidants, alongside saponins, phytosterols, and fatty acids. Indole alkaloids and specific fatty acids contribute to its antibacterial and antifungal attributes, while saponins may additionally support skin repair and wound healing processes. The extract also possesses inherent astringent qualities.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

10%

Key findings

  1. 01 An in vitro study utilizing a 10% (100 mg/mL) crude aqueous extract demonstrated maximum antibacterial activity against a range of pathogens, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Streptococcus pyogenes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

An optimal pH range for stability in cosmetic formulations has not been specified. It is important to note that some active chemical entities within Rauvolfia serpentina exhibit low water solubility, which may necessitate specialized formulation techniques, such as nanosuspensions, to enhance bioavailability and efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Regulatory assessments by bodies such as the Cosmetic Ingredient Review (CIR) or SCCS for RAUVOLFIA SERPENTINA ROOT EXTRACT in topical cosmetic use are currently unavailable, and no maximum safe concentration has been established. It is critical to differentiate topical application from oral ingestion, as oral use of Rauvolfia serpentina is associated with severe systemic side effects, including significant cardiovascular, neurological, and gastrointestinal disturbances. The absence of specific cosmetic topical safety data necessitates a cautious approach.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While offering promising in vitro antioxidant, anti-inflammatory, and antibacterial properties, the complete lack of topical safety assessments for cosmetic use makes its inclusion questionable for a precision skincare formulation.

Related

Similar Ingredients

Finding similar ingredients…