Science
Mechanism of Action
The precise mechanism of action for the combined R-(SH/S-MOUSE POLYPEPTIDE-2 SH-POLYPEPTIDE-118) is not fully elucidated in current public literature. However, its efficacy is understood through its two primary components. Sh-Polypeptide-2 functions as a synthetic growth factor, mirroring the activity of Thioredoxin (TRX). Under conditions of oxidative stress, it translocates into cell nuclei to provide cellular protection, neutralize free radicals, and mitigate oxidative damage and programmed cell death (apoptosis). This component further stimulates dermal cell organization and proliferation, fosters new skin cell generation, and crucially promotes collagen synthesis, thereby improving skin elasticity. Sh-Polypeptide-11, recognized as Acidic Fibroblast Growth Factor (aFGF), is instrumental in stimulating fibroblast proliferation, which in turn boosts the synthesis of both collagen and elastin. It actively supports skin regeneration, accelerates wound healing processes, and exhibits potent antioxidant capabilities, effectively reducing free radicals and counteracting cellular aging.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Specific safety evaluations for the combined R-(SH/S-MOUSE POLYPEPTIDE-2 SH-POLYPEPTIDE-118) by regulatory bodies such as CIR, SCCS, or FDA are currently unavailable. While related peptides, such as sh-Polypeptide-1, have demonstrated no irritation or general toxicity in topical applications, caution is advised due to its bFGF-mimetic nature, which has been associated with melanoma progression. Comprehensive safety data for this particular complex is required for a definitive assessment.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising mechanistic data from its component peptides suggesting potent anti-aging and regenerative properties, specific clinical efficacy and safety data for the combined R-(SH/S-MOUSE POLYPEPTIDE-2 SH-POLYPEPTIDE-118) are currently insufficient to draw definitive conclusions.
Related
Similar Ingredients
Finding similar ingredients…