Science
Mechanism of Action
This single-chain recombinant peptide is precisely engineered through E. coli fermentation, formed by the genetic fusion of sh-Polypeptide-2 and Decapeptide-40. Its multifaceted mechanism of action includes: 1. **Skin Conditioning & Protection**: It actively improves the skin's condition, contributing to a softer, smoother, and more hydrated feel. Simultaneously, it forms a protective barrier on the skin surface, shielding it from external aggressors such as pollution and UV radiation, thereby maintaining epidermal integrity. 2. **Cellular Regeneration & Wound Healing**: The sh-Polypeptide-22 component acts as a synthetic analog of human transforming growth factor beta 1 (TGFβ-1). It significantly stimulates cell proliferation and differentiation, promoting efficient wound healing through the activation of epithelial cells and fibroblasts. 3. **Extracellular Matrix Synthesis**: It is a potent stimulator for the synthesis of crucial structural proteins including collagen, elastin, and fibronectin, which are essential for maintaining skin firmness and elasticity. 4. **Microcirculation Enhancement**: The peptide encourages renewal of microvascular cells, leading to improved blood microcirculation within the skin, supporting nutrient delivery and cellular vitality. 5. **Pigmentation Modulation**: It demonstrates an inhibitory effect on tyrosinase activity, which is key in melanin production, thereby contributing to a reduction in hyperpigmentation and offering a skin brightening benefit. 6. **Anti-inflammatory & Immunomodulatory**: By suppressing pro-inflammatory cytokines, it exerts an anti-inflammatory effect and plays a role in regulating the skin's immune responses.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While comprehensive safety assessments by bodies such as CIR, SCCS, or FDA specifically for R-(SH-POLYPEPTIDE-22 DECAPEPTIDE-40) are not explicitly documented, adverse reactions and side effects are generally reported as uncommon. Its key component, sh-Polypeptide-22, is specifically noted as 'Irritant Free' and is considered safe for sensitive skin, infants, and delicate areas like the eyelids.
Your Skin
Skin Compatibility
Our Assessment
Verdict
R-(SH-POLYPEPTIDE-22 DECAPEPTIDE-40) is a valuable recombinant peptide offering a comprehensive range of benefits, from strengthening the skin barrier and promoting cellular regeneration to stimulating vital structural proteins and providing anti-inflammatory and brightening effects.
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References
Sources