Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

R-(SH-POLYPEPTIDE-22 DECAPEPTIDE-40).

Valuable / SKIN CONDITIONING - MISCELLANEOUS

R-(SH-POLYPEPTIDE-22 DECAPEPTIDE-40) is a sophisticated recombinant peptide designed to elevate overall skin health. It functions as a powerful skin conditioner and protective agent, visibly enhancing skin texture, hydration, and resilience. This ingredient also fortifies the skin's natural defenses against environmental stressors.

Skin Conditioning Skin Protecting Anti-aging Collagen Synthesis Elastin Synthesis Fibronectin Synthesis Wound Healing Cell Proliferation Cell Differentiation Microcirculation Improvement Melanin Inhibition Anti-inflammatory Immune Regulation Skin Brightening

Science

This single-chain recombinant peptide is precisely engineered through E. coli fermentation, formed by the genetic fusion of sh-Polypeptide-2 and Decapeptide-40. Its multifaceted mechanism of action includes: 1. **Skin Conditioning & Protection**: It actively improves the skin's condition, contributing to a softer, smoother, and more hydrated feel. Simultaneously, it forms a protective barrier on the skin surface, shielding it from external aggressors such as pollution and UV radiation, thereby maintaining epidermal integrity. 2. **Cellular Regeneration & Wound Healing**: The sh-Polypeptide-22 component acts as a synthetic analog of human transforming growth factor beta 1 (TGFβ-1). It significantly stimulates cell proliferation and differentiation, promoting efficient wound healing through the activation of epithelial cells and fibroblasts. 3. **Extracellular Matrix Synthesis**: It is a potent stimulator for the synthesis of crucial structural proteins including collagen, elastin, and fibronectin, which are essential for maintaining skin firmness and elasticity. 4. **Microcirculation Enhancement**: The peptide encourages renewal of microvascular cells, leading to improved blood microcirculation within the skin, supporting nutrient delivery and cellular vitality. 5. **Pigmentation Modulation**: It demonstrates an inhibitory effect on tyrosinase activity, which is key in melanin production, thereby contributing to a reduction in hyperpigmentation and offering a skin brightening benefit. 6. **Anti-inflammatory & Immunomodulatory**: By suppressing pro-inflammatory cytokines, it exerts an anti-inflammatory effect and plays a role in regulating the skin's immune responses.


Research

Medium confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Low

While comprehensive safety assessments by bodies such as CIR, SCCS, or FDA specifically for R-(SH-POLYPEPTIDE-22 DECAPEPTIDE-40) are not explicitly documented, adverse reactions and side effects are generally reported as uncommon. Its key component, sh-Polypeptide-22, is specifically noted as 'Irritant Free' and is considered safe for sensitive skin, infants, and delicate areas like the eyelids.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

R-(SH-POLYPEPTIDE-22 DECAPEPTIDE-40) is a valuable recombinant peptide offering a comprehensive range of benefits, from strengthening the skin barrier and promoting cellular regeneration to stimulating vital structural proteins and providing anti-inflammatory and brightening effects.


Related

Finding similar ingredients…