Science
Mechanism of Action
This ingredient is a unique fusion peptide, comprising 105 amino acids, created via recombinant DNA technology in E. coli by joining the genetic sequences for sh-Polypeptide-2 and Decapeptide-40. It acts to maintain optimal skin condition, fostering a softer, smoother, and more hydrated complexion. By forming a protective surface barrier, it helps shield the skin from external aggressors like pollution and UV radiation. The sh-Polypeptide-2 component, an engineered analog of human Thioredoxin, actively stimulates the proliferation of dermal cells, offers significant protection against oxidative stress by reducing free radicals, and strengthens the skin's natural defenses. Furthermore, it plays a role in regulating protein structure formation and modulating transcriptional factors, which contributes to an uplifted appearance, improved skin brightness, and a visible reduction in the appearance of fine lines and wrinkles.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For peptides generally, factors such as pH, electrical charge, molecular weight, and electrolyte balance can significantly influence skin permeation. Utilizing nano-sized carrier systems, such as nanoliposomes, has been demonstrated to improve the topical bioavailability and skin penetration of hydrophilic and polar peptide sequences, suggesting potential for enhanced delivery of this ingredient.
Safety
Safety Profile
R-(Sh-Polypeptide-2 Decapeptide-40) is generally considered safe for topical application in cosmetic formulations. Adverse reactions such as skin irritation, redness, or allergic responses are reported as uncommon. A patch test is recommended prior to extensive application. While the CIR has not specifically reviewed this exact combined peptide, it has evaluated 'Tissue-Derived Proteins and Peptides' as a broader category.
Your Skin
Skin Compatibility
Our Assessment
Verdict
R-(Sh-Polypeptide-2 Decapeptide-40) presents as a valuable recombinant peptide with a well-defined mechanistic pathway for skin conditioning, protection, and anti-aging benefits, though specific clinical efficacy data at defined concentrations is not yet available.
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References
Sources