Science
Mechanism of Action
This ingredient functions as a recombinant human peptide, specifically created by fusing the genes that code for sh-polypeptide-102 and sh-polypeptide-103. While detailed mechanisms for this exact fusion are not extensively documented, sh-polypeptides as a class are understood to promote the proliferation and regeneration of skin cells. They are known to aid in dermal repair and wound healing, stimulate the biosynthesis of collagen and elastin, and consequently reduce the appearance of fine lines and wrinkles while improving skin firmness and elasticity. Additionally, they can enhance moisture retention. Some sh-polypeptides also exhibit potential skin brightening effects by inhibiting melanin production and possess anti-inflammatory capabilities. It is important to note that sh-polypeptides typically do not penetrate the epidermal barrier of intact human skin under normal application, suggesting a primarily localized action.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not conducted a specific safety assessment for R-(SH-POLYPEPTIDE-102 SH-POLYPEPTIDE-103), though general categories of tissue-derived proteins and peptides have been evaluated. Manufacturers often assert general sh-polypeptide safety, citing intrinsic compatibility, biodegradability, and a lack of epidermal penetration in intact skin. However, these generalized claims do not specifically apply to this distinct fusion peptide.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its engineered design as a fusion of two polypeptides and the broad benefits associated with sh-polypeptides, there is insufficient specific data regarding the unique clinical efficacy or safety of R-(SH-POLYPEPTIDE-102 SH-POLYPEPTIDE-103) to fully assess its precise value.
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