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Moumoujus

R-(SH-OLIGOPEPTIDE-94 HEXAPEPTIDE-40).

Insufficient Data / ANTIOXIDANT

R-(SH-OLIGOPEPTIDE-94 HEXAPEPTIDE-40) is a sophisticated fusion peptide engineered to mimic key skin growth factors. It functions as a cell-communicating ingredient, signaling skin cells to enhance natural repair processes and boost the production of vital skin components, contributing to a more youthful and resilient complexion.

Summary

cell-communicating ingredient antioxidant anti-aging agent skin regeneration collagen production booster elastin production booster hyaluronic acid production booster wound healing support

Science

Mechanism of Action

This ingredient operates by interfacing with specific receptor sites on the skin's surface, acting as a cell-communicating agent. It supports the skin's intrinsic repair mechanisms, prompting the synthesis of essential structural proteins such as collagen and elastin, alongside hyaluronic acid. The sh-Oligopeptide-1 component, also known as Epidermal Growth Factor (EGF), plays a crucial role by binding to the epidermal growth factor receptor (EGFR). This binding stimulates skin cell proliferation, differentiation, and survival, strengthening the skin barrier. Furthermore, it enhances keratinocyte activity, supports fibroblast viability, elevates hyaluronic acid production, and actively promotes wound healing.

Research

Clinical Evidence

Low confidence
Effective range 1–2%
Optimal

N/A

Key findings

  1. 01 In a water-based formulation, a closely related peptide, 'hexapeptide-40 sh-oligopeptide-1', was associated with a visible reduction in the appearance of wrinkles when used at a 1-2% concentration.
  2. 02 A 2012 study involving a serum containing barley bioengineered epidermal growth factor (sh-Oligopeptide-1) demonstrated statistically significant improvements in fine lines, rhytids, skin texture, pore size, and various dyschromatic conditions, with continuous improvement noted over three months.

Transparency

Dusting Analysis

Not commonly dusted

There is no information to suggest this ingredient is commonly 'dusted' at sub-efficacious concentrations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not conducted a specific review of R-(SH-OLIGOPEPTIDE-94 HEXAPEPTIDE-40) or its related form, 'Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1'. While sh-oligopeptide-1 (sh-EGF), a component of this ingredient, is authorized for general cosmetic use, its long-term risks are not fully understood. Concerns have been raised that active EGF is considered an unauthorized drug, and clinical studies on sh-oligopeptide-1 have faced scrutiny regarding the lack of proven preclinical bioactivity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While related peptides show promising effects on wrinkle reduction and skin rejuvenation, the specific ingredient lacks comprehensive safety review and robust scientific substantiation for its preclinical bioactivity, warranting further research.

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