Science
Mechanism of Action
This complex operates primarily via SH-Polypeptide-9, a recombinant analog of human VEGFA, which functions as a pivotal cell signaling protein. Upon topical application, SH-Polypeptide-9 binds to specific receptors on endothelial cells, initiating angiogenesis—the formation of new blood vessels. This process significantly augments microcirculation within the skin, ensuring an optimal supply of essential nutrients and oxygen to the dermal layers. Enhanced blood flow directly supports cellular functions, nourishes fibroblasts, stimulates cell growth and migration, and accelerates wound healing. Furthermore, it boosts protein production for cellular restructuring and actively promotes collagen synthesis, leading to firmer, smoother, and more youthful-looking skin. The precise mechanism of SH-Oligopeptide-75 within this complex is not explicitly detailed.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Clinical research consistently demonstrates SH-Polypeptide-9's efficacy in enhancing skin health, repair processes, and overall resilience.
- 02 Studies indicate it significantly boosts the production of proteins vital for cellular restructuring, contributing to perceptibly smoother and firmer skin texture.
- 03 It improves vascular permeability, thereby enhancing nutrient and oxygen exchange within the skin, which is crucial for cellular rejuvenation and maintaining robust collagen levels.
- 04 In comparative hair growth applications, double-layer encapsulated SH-Polypeptide-9 exhibited superior activity in elevating VEGF, stimulating bFGF release, and increasing β-catenin production, notably at concentrations lower than Minoxidil.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific pH ranges for R-(SH-OLIGOPEPTIDE-75 SH-POLYPEPTIDE-9) or its primary component SH-Polypeptide-9 are not explicitly defined, peptides generally exhibit enhanced stability in buffered aqueous solutions within a pH range of 3-5. This range is known to mitigate deamidation and oxidation, alongside protecting disulfide bridges. Effective formulation strategies for peptides often involve the use of excipients such as amino acids, sugars, or buffer systems, co-solvents, air exclusion, viscosity enhancement, bivalent cations, PEGylation, and polyol excipients. For optimal stability, especially in aqueous injection formulations, storage at low temperatures and protection from light are highly recommended.
Conflicts
- Due to SH-Polypeptide-9 (VEGFA) activity potentially contributing to the progression of psoriasis, products containing this ingredient should be used with informed caution by individuals with this condition.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that 19 ectodermal-derived proteins and peptides, a category encompassing SH-Polypeptide-9, are safe for use in cosmetics under current practices and concentrations. The panel highlighted that daily systemic exposure to these proteins and peptides from food consumption is anticipated to be substantially greater than from cosmetic products. While a comprehensive lack of systemic toxicity data (e.g., reproductive, developmental, genotoxicity, carcinogenicity) was noted for some members of this group, the Panel did not foresee adverse systemic effects in the general population from cosmetic use. EWG Skin Deep classifies SH-Polypeptide-9 with a 'LOW' concern for cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions. SH-Polypeptide-9 is a synthetic recombinant analog of human VEGFA. Although the application of growth factors in skincare can be subject to debate, specific concerns regarding unsubstantiated claims for SH-Oligopeptide-1 (EGF) do not directly extend to SH-Polypeptide-9 (VEGF). No specific SCCS or FDA regulatory status was found for the R-(SH-OLIGOPEPTIDE-75 SH-POLYPEPTIDE-9) complex.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This complex, primarily utilizing SH-Polypeptide-9, offers significant regenerative and anti-aging benefits by potently enhancing microcirculation, accelerating cellular restructuring, and promoting collagen synthesis, making it a valuable active for advanced skincare and haircare formulations.
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