Science
Mechanism of Action
The active component, SH-Oligopeptide-2, a synthetic single-chain polypeptide, mimics the biological activity of naturally occurring IGF-1. It functions by activating cellular signaling pathways, notably the AKT pathway, which is vital for cellular health and anti-aging processes. When applied topically, it stimulates the proliferation of fibroblasts, leading to increased collagen synthesis, and enhances the biosynthesis of hyaluronic acid and other extracellular matrix (ECM) components. This multifaceted action contributes to improved skin elasticity, hydration, and overall firmness. Additionally, it promotes epidermal keratinocyte proliferation, supporting skin renewal, and is observed to revitalize aged cells while assisting in the regeneration of damaged tissues by fostering new blood vessel formation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The European Cosmetics Directive acknowledges SH-Oligopeptide-2 as permissible for cosmetic use, yet it strongly advises caution, recommending a sensitivity test due to the potential for allergy cases. While EWG Skin Deep rates SH-Oligopeptide-2 as a low concern for cancer and does not list it as restricted, there are significant warnings regarding growth factor-mimicking peptides. These are correlated with tumorigenesis or progression, and recombinant IGF-1 (SH-Oligopeptide-2) has been specifically linked to Melanoma progression.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While SH-Oligopeptide-2 offers potent anti-aging benefits by stimulating cellular regeneration and ECM synthesis, its classification as a growth factor-mimicking peptide with reported correlations to tumorigenesis and melanoma progression, alongside its 'not reviewed' CIR status, necessitates significant caution and further comprehensive safety evaluation for consistent topical application.
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References
Sources