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R-(SH-OLIGOPEPTIDE-4 DECAPEPTIDE-40).

Valuable / SKIN CONDITIONING

This advanced biomimetic peptide complex, R-(SH-OLIGOPEPTIDE-4 DECAPEPTIDE-40), is engineered to activate the skin's intrinsic repair mechanisms. It robustly stimulates the production of vital extracellular matrix proteins such as collagen, elastin, and hyaluronic acid, leading to noticeable improvements in skin elasticity, density, and a reduction in the appearance of fine lines and wrinkles. Furthermore, it supports a healthy skin barrier and imparts a softer, more hydrated feel.

Summary

Skin-conditioning Anti-aging Wrinkle reduction Improves skin elasticity Enhances skin firmness Increases skin density Supports skin barrier function Skin protection (environmental aggressors) Moisturizing Promotes wound healing Addresses hyperpigmentation Supports acne management Hair conditioning

Science

Mechanism of Action

R-(SH-OLIGOPEPTIDE-4 DECAPEPTIDE-40) functions as a sophisticated signaling peptide, mimicking natural growth factors to prompt the skin's endogenous repair systems. It precisely targets dermal fibroblasts, initiating the increased synthesis of crucial structural proteins and humectants, specifically collagen, elastin, and hyaluronic acid. This action not only enhances skin elasticity, density, and thickness but also visibly diminishes the depth of lines and wrinkles. Beyond its structural benefits, this complex contributes to improved skin texture, fostering a smoother, softer, and more hydrated complexion. Additionally, it can form a protective surface barrier against environmental aggressors. One of its constituent peptides, sh-Oligopeptide-4, actively promotes collagen deposition for accelerated wound recovery and demonstrates efficacy in reducing hyperpigmentation and combating acne breakouts.

Research

Clinical Evidence

Medium confidence
Effective range 0.002–0.1%
Optimal

N/A

Key findings

  1. 01 Studies on Decapeptide-4, a key component of this complex, reveal its capacity to stimulate the synthesis of essential skin components including collagen, elastin, and hyaluronic acid. This leads to demonstrable improvements in skin elasticity, density, and thickness, alongside a visible reduction in fine lines and wrinkles. These benefits were observed in research formulations utilizing Decapeptide-4 at concentrations between 0.01% and 0.1%.
  2. 02 Further research indicates Decapeptide-4's application in cosmetic formulations at concentrations ranging from 0.002% to 0.005% for its reported anti-wrinkle, skin lifting, and hair growth properties.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

This ingredient exhibits water solubility, making it versatile for aqueous formulations. For optimal stability, the Decapeptide-4 component functions best within a pH range of 5 to 7. While comprehensive stability data for the entire R-(SH-OLIGOPEPTIDE-4 DECAPEPTIDE-40) complex is not explicitly detailed, standard peptide handling practices, such as avoiding extreme pH variations and high temperatures, are recommended to preserve its efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

As of current review, R-(SH-OLIGOPEPTIDE-4 DECAPEPTIDE-40) does not have a specific safety assessment from CIR, SCCS, or FDA. However, a structurally analogous compound, R-(Sh-Polypeptide-2 Decapeptide-40), is broadly considered safe for topical cosmetic use. Although rare, minor side effects like skin irritation, redness, or allergic reactions have been noted with similar peptide ingredients, making patch testing advisable for sensitive individuals. Notably, its sh-Oligopeptide-4 component has been independently recognized as 'Irritant Free' by SkinSAFE.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This sophisticated peptide complex represents a valuable ingredient for advanced skincare, offering significant benefits in stimulating skin's regenerative processes, enhancing structural integrity, and improving overall dermal health and appearance.

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