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Moumoujus

R-SALMON OLIGOPEPTIDE-1.

Valuable / ANTIOXIDANT, SKIN PROTECTING

R-SALMON OLIGOPEPTIDE-1 is a sophisticated recombinant polypeptide designed to act as a potent skin-conditioning and regenerative agent. This ingredient is engineered to activate the skin's natural repair mechanisms, promoting a more resilient and youthful complexion.

Summary

Cell-communicating ingredient Antioxidant Skin-identical ingredient Skin-conditioning Epidermal regeneration Collagen booster Soothing

Science

Mechanism of Action

This peptide functions as an Epidermal Growth Factor (EGF), binding to specific Epidermal Growth Factor Receptors (EGFRs) to stimulate cellular growth, proliferation, healing, and differentiation within the epidermis. It proactively encourages the regeneration of mature skin cells, helping to reinforce skin structure and mitigate age-related thinning. Furthermore, R-SALMON OLIGOPEPTIDE-1 bolsters the skin's barrier function, promotes collagen synthesis, and provides antioxidant protection, leading to visible reduction in wrinkles, redness, and inflammation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of an EGF serum has been shown to accelerate wound healing in various medical and aesthetic contexts.
  2. 02 A study involving twice-daily application of a topical EGF serum for 8 weeks resulted in a decrease in melasma in 73% of subjects, with no reported side effects.
  3. 03 An EGF cream applied to half the face over a six-week period reduced inflammatory acne lesions by 33.5% in a study of 20 subjects.
  4. 04 A broader salmon egg extract, containing various active substances (not pure R-SALMON OLIGOPEPTIDE-1), demonstrated dose-dependent and time-dependent efficacy at 1% and 5% concentrations, significantly improving wrinkles, pigmentation, redness, brightness, and hydration without causing skin irritation or sensitization.

Transparency

Dusting Analysis

Not commonly dusted

As a specialized, recombinant peptide with specific formulation requirements, R-SALMON OLIGOPEPTIDE-1 is generally not anticipated to be included at sub-effective 'dusting' concentrations.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

R-SALMON OLIGOPEPTIDE-1 is highly sensitive to pH; formulations should be adjusted to a pH between 5.0 and 8.0 prior to its incorporation. It is also susceptible to enzymatic decomposition by microorganisms, necessitating stringent control over microbial contamination during processing to maintain its activity and usefulness.

Conflicts

  • Microbial contamination (can lead to enzymatic decomposition and loss of activity)
  • Problematic ingredients (may increase irritation risk)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

R-SALMON OLIGOPEPTIDE-1 has not undergone specific safety review by CIR or SCCS. While the CIR Panel noted that broader categories of 'Tissue-Derived Proteins and Peptides' are unlikely to cause systemic toxicity, the FDA requires allergen labeling for fish in food, and fish proteins are recognized food allergens. Sources also indicate 'unknown long-term risks' for active EGF and some concerns regarding its preclinical bioactivity, despite its authorization as a cosmetic ingredient. Although generally considered non-irritating, there is a noted likelihood of irritation, which may increase when combined with other problematic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

R-SALMON OLIGOPEPTIDE-1 is a valuable, multifaceted peptide offering significant regenerative and anti-aging benefits, yet requires precise formulation and careful consideration of its unreviewed safety profile and potential for irritation.

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