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Moumoujus

R-(S-RAINBOW TROUT OLIGOPEPTIDE-1 SH-POLYPEPTIDE-58).

Questionable / ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

This complex biomimetic peptide combines Epidermal Growth Factor (sh-Oligopeptide-1) and Fibroblast Growth Factor (sr-Rainbow Trout Oligopeptide-1). It is engineered to stimulate cellular regeneration, promote collagen and elastin synthesis, and enhance the skin's inherent repair mechanisms for improved skin vitality and structure.

Summary

Skin Cell Renewal Collagen & Elastin Synthesis Support Wound Healing Enhancement Skin Barrier Reinforcement Hyaluronic Acid Production Boost Antioxidant Skin Protecting Hair Conditioning

Science

Mechanism of Action

This advanced peptide complex functions by engaging specific growth factor receptors within dermal cells. The sh-Oligopeptide-1 component, an Epidermal Growth Factor mimetic, precisely binds to epidermal growth factor receptors (EGFR) on keratinocytes, initiating pathways for cell proliferation, differentiation, and tissue repair. This interaction additionally promotes the de novo synthesis of crucial structural proteins like collagen and elastin, enhances wound healing, fortifies skin barrier integrity, and upregulates hyaluronic acid production. Concurrently, the sr-Rainbow Trout Oligopeptide-1, acting as a Fibroblast Growth Factor (FGF), further supports comprehensive skin regeneration and aids in the continuous synthesis of collagen and elastin, contributing to robust skin architecture.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 No direct clinical studies are available for R-(S-RAINBOW TROUT OLIGOPEPTIDE-1 SH-POLYPEPTIDE-58). Efficacy is inferred from studies on related peptide combinations (e.g., sr-Rainbow Trout Oligopeptide-1 sh-Polypeptide-13, -2, -1, -8, -9) used in hair growth, skin protectant, and acne formulations, at concentrations such as 0.0001%. However, clinical studies on sh-Oligopeptide-1 (Epidermal Growth Factor, a key component) have faced criticism for lacking robust scientific methodology or utilizing inactive ingredients.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Optimal stability is maintained when products are stored within a temperature range of 2-25°C (36-77°F). Exposure to freezing temperatures or excessive heat exceeding 40°C (104°F) should be strictly avoided to preserve ingredient integrity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not assessed this specific peptide. The FDA has issued disclaimers for drug products containing similar peptide combinations, noting unapproved labeling and unproven safety/efficacy. While sh-Oligopeptide-1 (EGF) is authorized as a cosmetic component, it carries 'unknown long-term risks'. Inconclusive evidence suggesting EGF may promote existing cancerous tumors raises significant caution, especially for individuals with a history of skin cancer.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While theoretically promising for skin rejuvenation through growth factor mimetics, this ingredient warrants caution due to an absence of specific clinical data, 'unknown long-term risks' associated with its EGF component, and unresolved concerns regarding potential tumor promotion.

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