Science
Mechanism of Action
This ingredient functions as an antioxidant, directly contributing to the protection of skin cells from oxidative damage. Its structure incorporates sh-Oligopeptide-1, an Epidermal Growth Factor (EGF) equivalent, which is known to stimulate cell proliferation, differentiation, and tissue repair. Additionally, sh-Polypeptide-4, related to Stem Cell Factor, may support cellular regeneration, collagen and elastin synthesis, and aid in maintaining a robust skin barrier. However, the detailed synergistic mechanisms for this specific combined ingredient require further elucidation through dedicated research.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not yet reviewed the safety of this ingredient. A significant concern arises from a DailyMed listing of products containing similar 'sr-Rainbow Trout Oligopeptide-1 sh-polypeptide' ingredients, for which the FDA explicitly states they 'have not been found by FDA to be safe and effective.' Furthermore, the long-term risks associated with cosmetic-grade sh-oligopeptide-1 (an EGF equivalent) are currently unknown, with some reviews also noting a lack of proven preclinical bioactivity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While offering theoretical benefits as an antioxidant and skin protectant, the absence of specific clinical efficacy data, its 'not reviewed' CIR status, and explicit FDA concerns regarding similar compounds render this ingredient's inclusion questionable for precision skincare.
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