R-PEANUT RICE CALLUS EXTRACT.

This resveratrol-enriched extract functions as a potent antioxidant by effectively scavenging free radicals, thereby mitigating oxidative stress. Its anti-melanogenesis action involves a multi-faceted approach: it decreases melanin-containing cells, suppresses tyrosinase activity and melanin content, downregulates key gene expressions (MITF, tyrosinase, TRP-1, TRP-2), while simultaneously activating phosphorylated ERK1/2 and PKB, and inhibiting phosphorylated p38. For anti-inflammatory effects, it reduces LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, and suppresses the upregulation of proinflammatory genes such as iNOS, COX-2, IL-1β, IL-6, TNF-α, and TLR-4, primarily by inhibiting MAPK and NF-κB pathway activation. In anti-aging and wound healing contexts, it promotes cellular proliferation and rejuvenation, enhances keratinocyte migration, stimulates collagen synthesis in fibroblasts, increases dermatopontin expression, and provides protection against UV-induced damage, alongside improving the skin's natural moisture retention. For hair, it stimulates human dermal papilla cell proliferation, increases critical growth factors (IGF-1, KGF, HGF), inhibits 5α-reductase activity, and reduces oxidative stress and inflammation within the hair follicle to promote healthy growth and prevent loss.