Science
Mechanism of Action
The proposed mechanism involves stimulating key skin cells, specifically fibroblasts and keratinocytes. By activating these cells, the peptide could promote the synthesis of essential structural components, thereby contributing to improved skin resilience and overall health.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Due to its significant molecular size, R-(OLIGOPEPTIDE-133 SH-POLYPEPTIDE-11) is anticipated to require a sophisticated delivery system, such as lipid spheres (liposomes), for optimal penetration through the stratum corneum. This targeted delivery would facilitate its access to deeper skin layers to effectively stimulate fibroblasts and keratinocytes.
Safety
Safety Profile
No specific safety assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) are documented for R-(OLIGOPEPTIDE-133 SH-POLYPEPTIDE-11). While sh-Polypeptide-11, a constituent of this fusion peptide, is recognized with an FDA UNII (G53298VN9Y), EWG Skin Deep identifies it as 'Restricted' for EWG VERIFIED products without comprehensive substantiation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While R-(OLIGOPEPTIDE-133 SH-POLYPEPTIDE-11 presents as a promising fusion peptide for cellular stimulation, a lack of specific clinical efficacy studies and comprehensive safety reviews necessitates further research to establish its precise benefits and optimal application.
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References
Sources