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Moumoujus

R-(OLIGOPEPTIDE-133 SH-OLIGOPEPTIDE-1).

Insufficient Data / SKIN CONDITIONING

R-(OLIGOPEPTIDE-133 SH-OLIGOPEPTIDE-1) is a specialized peptide incorporating the benefits of SH-Oligopeptide-1, commonly known as Epidermal Growth Factor (EGF). This growth factor component is designed to stimulate cellular processes fundamental to skin health, targeting regeneration and renewal.

Summary

Cellular Regeneration Anti-aging Skin Repair Barrier Function Improvement Moisturization Collagen Synthesis Elastin Synthesis Hyaluronic Acid Production Anti-inflammatory

Science

Mechanism of Action

This ingredient primarily functions through its SH-Oligopeptide-1 component, which acts as an Epidermal Growth Factor (EGF). EGF precisely binds to epidermal growth factor receptors (EGFR) on skin cells, particularly keratinocytes. This binding initiates a cascade of intracellular signals that promote critical cellular activities, including increased cell division, growth, and differentiation. Furthermore, it enhances skin repair mechanisms by accelerating self-regeneration, stimulating the formation of new blood vessels, boosting endogenous rejuvenating growth factors, and reinforcing the skin's barrier function. It also contributes to minimizing inflammatory responses, reducing the appearance of cutaneous scars, providing long-term hydration, and increasing the production of vital extracellular matrix components like collagen, elastin, and hyaluronic acid.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Information regarding 'dusting' or common misuse as a marketing ingredient without sufficient concentration is not available in the provided research data.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

This ingredient, specifically its Oligopeptide-1 component, demonstrates significant pH sensitivity. Optimal stability is maintained within a pH range of 5 to 8. Formulations should have their pH adjusted within this range before the addition of the diluted EGF solution. Vigilant avoidance of microbial contamination during processing is crucial, as enzymatic degradation by microorganisms can compromise its stability and efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA for R-(OLIGOPEPTIDE-133 SH-OLIGOPEPTIDE-1) are currently unavailable. While sh-Oligopeptide-1 (EGF) is authorized for general cosmetic use, its long-term risks are not fully understood. It is classified as mitogenic, meaning it stimulates cell proliferation, but it is not considered mutagenic. Due to its mitogenic nature, caution is advised for individuals with pre-existing skin cancer risk factors or psoriasis, as EGF could theoretically support the proliferation of existing cancerous cells. Reported side effects are generally minor, however, further comprehensive research specific to this complex peptide is required to establish its full safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While the SH-Oligopeptide-1 component (EGF) offers significant theoretical benefits for skin regeneration and repair, the lack of specific clinical studies and safety assessments for R-(OLIGOPEPTIDE-133 SH-OLIGOPEPTIDE-1) necessitates further research for a definitive Moumoujus endorsement.

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