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Moumoujus

R-MUSSEL POLYPEPTIDE-2.

Valuable / NOT REPORTED

R-MUSSEL POLYPEPTIDE-2 is a bio-engineered peptide derived from mussel adhesive protein, specifically engineered to restore compromised skin barriers and mitigate inflammatory responses. It supports advanced skin repair and regeneration, making it valuable for sensitive and damaged skin conditions.

Summary

skin-conditioning antioxidant anti-inflammatory wound healing barrier repair anti-aging antibacterial cell-protective

Science

Mechanism of Action

This recombinant mussel adhesive protein acts at a cellular level by modulating key inflammatory pathways. It downregulates the expression of P-p65/p65 and Keap1, while concurrently upregulating Nrf2, thereby inhibiting NF-κB and activating the Keap1/Nrf2 signaling pathway. This dual action leads to significant anti-inflammatory benefits and reinforces the skin's natural barrier. Additionally, it exhibits antioxidant prowess by scavenging ABTS and DPPH radicals, offers anti-aging benefits through the inhibition of collagenase and hyaluronidase enzymes, and promotes epidermal regeneration via its antibacterial and cell-protective effects.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Pre-clinical studies in mouse models of atopic dermatitis demonstrated that recombinant mussel adhesive protein significantly improved compromised skin barriers, reduced scratching frequency, decreased transepidermal water loss, and lowered inflammatory factors, thereby ameliorating skin inflammation damage.
  2. 02 Clinical validation has shown rMAP-based products to be effective in skin repair, particularly for non-chronic wounds. They are suitable for addressing skin concerns such as post-laser or photorejuvenation irritation, various forms of dermatitis, eczema, general sensitive skin conditions, and acne.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Mussel proteins typically exhibit high solubility across acidic and alkaline pH ranges during extraction processes. While protein stability is generally influenced by pH, specific optimal pH conditions for R-MUSSEL POLYPEPTIDE-2's stability within cosmetic formulations are not currently specified.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

R-MUSSEL POLYPEPTIDE-2 has not undergone specific review by major regulatory bodies such as CIR, SCCS, or FDA. General CIR safety assessments for similar tissue-derived proteins and peptides often deem them safe for cosmetic use as skin or hair conditioning agents. However, it is crucial to note that fish proteins are recognized food allergens that can trigger Type I immediate hypersensitivity reactions upon ingestion. Case reports suggest individuals with existing fish allergies may experience reactions to topically applied fish-derived cosmetic ingredients, warranting caution for this specific population.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

R-MUSSEL POLYPEPTIDE-2 is a valuable active ingredient, demonstrating robust efficacy in barrier repair, inflammation reduction, and advanced skin regeneration, making it suitable for a wide range of targeted skincare applications.

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