Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

R-(METHIONYL SH-POLYPEPTIDE-1 DECAPEPTIDE-47).

Questionable / SKIN CONDITIONING

This recombinant fusion peptide is designed as a skin conditioning agent, theoretically stimulating cellular proliferation and the synthesis of structural proteins such as collagen and elastin. It aims to enhance skin elasticity, mitigate the appearance of wrinkles, and support overall skin regeneration processes.

Summary

Skin conditioning Anti-aging Wrinkle reduction Skin elasticity improvement Collagen synthesis booster Elastin synthesis booster Cell proliferation stimulant Hyaluronic acid production booster Skin regeneration

Science

Mechanism of Action

This ingredient functions as a recombinant fusion peptide, combining characteristics of sh-Polypeptide-1 (an analog of basic Fibroblast Growth Factor) and sh-Polypeptide-47 (peptides and collagen fragments). sh-Polypeptide-1 is hypothesized to act as a mitogen, promoting cell proliferation, particularly fibroblast growth. This stimulation is theorized to boost collagen and elastin production, thereby improving skin elasticity, reducing wrinkles, and potentially increasing hyaluronic acid synthesis. sh-Polypeptide-47 is believed to mimic the skin's natural repair mechanisms. The combined action is proposed to condition and protect the skin, while stimulating cellular growth and the synthesis of key extracellular matrix components.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A significant review highlighted that clinical studies pertaining to sh-oligopeptide-1 (a core component of this ingredient) frequently lack a robust scientific foundation, with unproven preclinical bioactivity. (Source: Topical application of sh-oligopeptide-1 and clinical trials with cosmetic preparations: risk or fraud? - PubMed)

Transparency

Dusting Analysis

Not commonly dusted

No data indicates that this ingredient is commonly used in sub-efficacious concentrations. However, concerns regarding the fundamental scientific basis and unproven preclinical bioactivity of sh-oligopeptide-1, a key component, raise questions about its overall efficacy irrespective of concentration.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Due to its relatively large molecular size, optimal stability, skin penetration, and efficacy of sh-Polypeptide-1 are frequently enhanced through encapsulation in delivery systems such as liposomes or PLGA-coated nanoparticles. Its recombinant fusion protein design may also contribute to improved intrinsic stability and solubility.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA assessments for R-(METHIONYL SH-POLYPEPTIDE-1 DECAPEPTIDE-47) were identified. Safety studies on sh-Polypeptide-1, a component, generally indicated no irritation, general toxicity, or significant adverse effects from topical application. Nevertheless, caution is advised for formulations containing ingredients mimicking sh-bFGF (a mimetic of sh-Polypeptide-1) due to an observed association between bFGF and Melanoma progression.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite a promising theoretical mechanism for skin regeneration and anti-aging benefits, the overall efficacy of this ingredient is questionable due to a documented lack of scientific basis and unproven preclinical bioactivity for its key component, sh-oligopeptide-1.

Related

Similar Ingredients

Finding similar ingredients…