Science
Mechanism of Action
This ingredient is a singular, recombinant fusion peptide, engineered through fermentation in E. coli by combining genetic material from r-Clostridium Histolyticum Collagenase and sh-Oligopeptide-60. As a peptide, it serves as a skin conditioning agent, signaling to activate the skin's endogenous repair processes. In cosmetic applications, this ingredient is hypothesized to stimulate the regeneration of mature skin, fortify its structural integrity, and contribute to a visible reduction in wrinkles, thereby improving complexion and overall skin elasticity. The collagenase component specifically acts by digesting both undenatured and denatured collagen through the hydrolysis of peptide bonds at physiological pH.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data available to suggest this ingredient is commonly dusted in cosmetic formulations.
The Formula
Formulation
Stability
The collagenase enzyme component maintains optimal activity and stability within a pH range of 6.3 to 8.8. However, formulators should be aware that this ingredient may present aesthetic, stability, or other issues that could limit its utility in certain formulations.
Conflicts
- ethylene glycol-bis(beta-aminoethyl ether) - N, N, N′,N′-tetraacetic acid (EGTA)
- beta-mercaptoethanol
- glutathione
- thioglycolic acid
- 8-hydroxyquinoline
Safety
Safety Profile
No specific safety assessments from the CIR or SCCS have been published for R-CLOSTRIDIUM HISTOLYTICUM COLLAGENASE RH-OLIGOPEPTIDE-60 as a cosmetic ingredient. While related injectable formulations of Collagenase Clostridium Histolyticum are FDA-approved for medical conditions such as cellulite, Dupuytren's contracture, and Peyronie's disease, this approval does not extend to the topical cosmetic ingredient. Comprehensive dermal toxicity data for topical applications is not readily available. Industry sources indicate a potential for irritation, inflammation, or dryness, with this risk possibly increasing when combined with other problematic ingredients.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite a promising mechanism for skin conditioning and structural improvement, the absence of specific topical clinical efficacy data and comprehensive safety assessments for cosmetic use, coupled with a noted irritation potential, suggests a cautious approach is warranted due to insufficient information.
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