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Moumoujus

R-CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1.

Valuable / SKIN CONDITIONING

R-CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1 is an innovative recombinant peptide, derived from the active 'Light Chain' of botulinum toxin and integrated with a Macro-molecule Transmission Domain. This advanced ingredient is engineered for topical application to precisely target signs of aging, reducing the appearance of lines and wrinkles while enhancing skin elasticity and overall complexion.

Summary

Skin protecting Skin conditioning

Science

Mechanism of Action

This precision peptide leverages a sophisticated Macro-molecule Transmission Domain (MTD) to facilitate enhanced transdermal delivery, ensuring penetration into the stratum corneum and deeper skin layers. The active 'Light Chain' component then functions as a skin conditioning agent, signaling the skin's intrinsic repair mechanisms. Unlike injectable botulinum toxin, which temporarily paralyzes muscle fibers, this cosmetic peptide aims to achieve similar anti-aging benefits topically, promoting mitigation of lines and wrinkles, and improving skin complexion and elasticity without inducing muscle paralysis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH 2.7 – 10.2
0 7 14

Stability

The ingredient demonstrates robust stability across a broad pH range, specifically between pH 2.7 and 10.2. While the full botulinum toxin complex has shown optimal stability in liquid formulations at pH 5-6 (ideally 5.4-5.8) when refrigerated, and is sensitive to physical agitation or bubbling, these insights suggest a generally stable yet nuanced formulation profile for this peptide.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

R-CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1 has not undergone specific review by the Cosmetic Ingredient Review (CIR) or SCCS. It is imperative to distinguish this topical cosmetic peptide from the full botulinum toxin, which is FDA-approved for injectable medical and cosmetic applications but explicitly prohibited for topical use in cosmetic products. This peptide, particularly its derivative 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40', holds the distinction of being 'The First Botulinum Ingredient on ICID' for cosmetic use, signifying its non-toxic, cosmetic-grade nature. While adverse reactions to related cosmetic peptides are uncommon, a preliminary patch test is advised. Due to a lack of specific data on topical usage during pregnancy and breastfeeding, consultation with a healthcare professional is recommended for these individuals.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This advanced peptide is a valuable asset in anti-aging formulations, leveraging targeted delivery to reduce wrinkles and enhance skin's youthful appearance, though precise topical dosage data is still emerging for optimal efficacy.

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