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Moumoujus

R-BACILLUS LICHENIFORMIS KERATINASE.

Insufficient Data / NAIL CONDITIONING, SKIN CONDITIONING

R-BACILLUS LICHENIFORMIS KERATINASE is a protease enzyme derived from *Bacillus licheniformis* engineered to precisely break down keratin proteins. It is integrated into skincare and nail products for its conditioning properties, aiming to maintain skin health and improve the aesthetic characteristics of nails.

Summary

Skin conditioning Nail conditioning

Science

Mechanism of Action

This ingredient functions as a proteolytic enzyme, specifically a keratinase, which precisely targets and cleaves peptide bonds within complex keratin structures. This enzymatic action degrades keratin into smaller peptides or individual amino acids, thereby contributing to its role in skin and nail conditioning.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific clinical efficacy studies with defined dose ranges or optimal percentages were found in the provided data to evaluate potential 'dusting' claims.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

R-BACILLUS LICHENIFORMIS KERATINASE is water-soluble and exhibits optimal enzymatic activity at a pH of 6.0, maintaining over 60% activity within the pH range of 6.0 to 8.0. Some variants of *Bacillus licheniformis* keratinases may demonstrate optimal activity at higher pH values, up to 9.0, with certain strains reported to be stable across a broad range from pH 5.0 to 12.0.

Conflicts

  • PMSF (phenylmethanesulfonyl fluoride) - acts as a serine protease inhibitor.
  • EDTA (ethylene diamine tetraacetic acid) - may inhibit some keratinases, suggesting a metalloprotease characteristic for those specific variants.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The European Commission's CosIng database lists R-BACILLUS LICHENIFORMIS KERATINASE with accepted functions for skin and nail conditioning, implying its permissibility within EU cosmetics. However, it has not been reviewed by the CIR, and specific SCCS opinions are unavailable. Comprehensive toxicity data, including GHS classifications or parameters for oral, dermal, and inhalation toxicity, have not been determined according to available information.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While R-BACILLUS LICHENIFORMIS KERATINASE offers a specific enzymatic mechanism for skin and nail conditioning and has defined formulation parameters, comprehensive data on its clinical efficacy and detailed safety profile for cosmetic use remain largely undetermined.

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