Science
Mechanism of Action
This extract functions as a powerful antioxidant by actively scavenging free radicals and inhibiting oxygen-promoted reactions, thereby safeguarding skin components from oxidative damage. Its astringent qualities help contract and tighten the skin, effectively regulating sebum production, minimizing the appearance of pores, and reducing excess oil. Furthermore, it demonstrates antimicrobial activity, offering protection against microbial proliferation. As a skin conditioning agent, it forms a protective barrier, preventing moisture loss and lubricating the skin for a smooth, soft feel. The extract also exerts anti-inflammatory effects by moderating inflammation and oxidative injuries within skin fibroblasts and reducing the expression of inflammation-related genes. Preliminary evidence also suggests a role in supporting wound healing through enhanced cell proliferation, re-epithelialization, and granulation tissue formation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A topical ointment significantly reduced wound area in diabetic animal models (mice), indicating strong wound healing potential.
- 02 Demonstrated improved wound closure and completely inhibited hydrogen peroxide-induced cellular Reactive Oxygen Species (ROS) production in L929 fibroblasts, highlighting potent antioxidant and healing support.
- 03 Significantly decreased nitric oxide production and enhanced phagocytic activity in murine macrophages, indicating anti-inflammatory and immunomodulatory effects.
- 04 No cytotoxic effects were observed in L929 fibroblasts, suggesting a good safety profile at relevant in vitro concentrations.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
A primary active component, tannic acid, is water-soluble but can undergo oxidation when dissolved in water, transforming into carbonic and gallic acids. This suggests formulations should either incorporate the extract at the point of use or include stabilizers to mitigate oxidation and maintain efficacy.
Safety
Safety Profile
Official safety assessments by CIR, SCCS, or FDA are currently unavailable. The Good Scents Company categorizes oral/parenteral and dermal toxicity as 'not determined'. However, studies on 'Quercus infectoria gall extract' (often used interchangeably in cosmetic literature due to shared active compounds) have indicated non-toxicity in specific extraction methods and 'no penalty' ratings across all categories by INCI Beauty, suggesting a generally favorable safety outlook for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Quercus Infectoria Fruit Extract is a valuable ingredient, offering broad benefits from antioxidant and anti-inflammatory properties to astringency and wound healing support, suitable for diverse skin types despite limited human topical clinical data.
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