Science
Mechanism of Action
This extract, abundant in key phenolic compounds such as gallic acid, ellagic acid, flavonoids, and tannins, exerts significant antioxidant and anti-inflammatory effects. It functions by mitigating oxidative stress and reducing dermal inflammation, while also promoting skin renewal through fibroblast migration and the upregulation of wound-healing markers. The extract strengthens the skin's protective barrier, soothes irritation, decreases skin sensitivity, and enhances microcirculation. Its tannin content also contributes astringent properties, and antimicrobial effects have been reported for oak extracts.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Studies on isolated galloyl derivatives from *Quercus glauca* Thunberg stem barks, such as 1,2,3,6-tetragalloylglucose (IC50: 32.3 μM) and 6'-O-galloyl salidroside (IC50: 224 μM), demonstrated potent inhibitory activity against the classical pathway complement system in vitro, indicating direct anti-inflammatory action.
- 02 In vitro research showed a concentration-dependent increase in radical scavenging activity for *Quercus gilva* extract (a related species containing *Quercus glauca*) across a range of 3.125-100 μg/mL, highlighting its antioxidant potential.
- 03 While specific clinical efficacy data for wound re-epithelialization directly for *Quercus glauca* stem extract is not detailed, the extract's rich phenolic composition is posited to support these benefits, drawing parallels to findings where *Quercus glauca* acorn seed coat extract at 0.1-10 μg/mL promoted wound closure in human dermal fibroblasts.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Extracts from Quercus species, especially those rich in polyphenols and tannins, generally exhibit robust stability for up to one year, maintaining antioxidant capacity and chemical integrity when formulated using hydroalcoholic solvents.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not specifically evaluated Quercus Glauca Stem Extract. While general oak extracts are broadly considered safe, individual sensitivities or allergic reactions may occasionally manifest.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Quercus Glauca Stem Extract is a valuable botanical ingredient, rich in phenolic compounds, offering significant antioxidant, anti-inflammatory, and purported wound-healing benefits, making it a promising addition to precision skincare formulations.
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