Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

QUERCETIN DIMETHYL ETHER GLUCOSIDE.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

Quercetin Dimethyl Ether Glucoside is a flavonoid glycoside distinguished by its potent anti-inflammatory properties and its capacity to enhance the skin's natural barrier function. This advanced derivative of quercetin actively works to soothe inflammation and fortify the skin's protective mechanisms, rendering it particularly beneficial for compromised or sensitive skin states.

Summary

Skin Conditioning Skin Protecting

Science

Mechanism of Action

This specialized form of quercetin, specifically Quercetin 3,7-dimethyl ether 4′-glucoside (QDG), operates on the skin by significantly inhibiting inflammation-related cytokines and chemokines. It also actively enhances the activation of crucial skin barrier factors and attenuates the phosphorylation inhibition of upstream cytokines and nuclear factor-κB expression. Broadly, related quercetin compounds exhibit antioxidant properties by mitigating lipid peroxidation and oxidative damage, alongside anti-inflammatory effects achieved through the inhibition of inflammatory receptors and their signaling pathways.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In human keratinocytes, Quercetin 3,7-dimethyl ether 4′-glucoside (QDG) significantly inhibited inflammation-related cytokines and chemokines. It also enhanced the activation of skin barrier factors and attenuated phosphorylation inhibition of upstream cytokines and nuclear factor-κB expression.

Transparency

Dusting Analysis

Not commonly dusted

No available data suggests that Quercetin Dimethyl Ether Glucoside is commonly associated with dusting during formulation processes.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While specific stability data for Quercetin Dimethyl Ether Glucoside is currently not documented, its glucoside (sugar) moiety typically improves water solubility compared to its aglycone. It is important to note that the parent compound, quercetin, has limited stability, being stable for approximately 4.5 hours within a pH range of 6.0-8.0 when stored at 4°C in the dark. Formulators should consider these general characteristics of the quercetin family.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from major regulatory bodies such as CIR, SCCS, or FDA have been found for Quercetin Dimethyl Ether Glucoside. General quercetin has shown genotoxic effects in certain *in vitro* assays but not in oral studies, and it is no longer considered carcinogenic. Further targeted safety assessments for this specific derivative would enhance its profile.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Quercetin Dimethyl Ether Glucoside is a valuable ingredient, demonstrating significant anti-inflammatory and skin barrier-enhancing benefits in laboratory studies, making it promising for dry and sensitive skin, although more specific in-vivo and safety data would further solidify its standing.

Related

Similar Ingredients

Finding similar ingredients…